New molecular mechanisms of aging regulation

Ilke Sen

    Research output: ThesisThesis fully internal (DIV)

    395 Downloads (Pure)

    Abstract

    Aging is a complex phenomenon, resulting from damage accumulation, the increased deregulation of biological pathways, and a loss of cellular homeostasis, all of which lead to a functional decline in the organism over time. Interestingly, aging is not a static process but it is highly regulated by an interconnected signaling network that predominantly regulates the activity of aging-preventive stress response and longevity promoting pathways. In this thesis, I provided new mechanistic insights into the transcriptional regulation of genes that promote stress resistance and longevity. For this work, I used the model organism C. elegans and focused on maybe the most central aging-regulatory signaling pathway known to date, namely insulin/IGF-like signaling (IIS) with its downstream transcription factor DAF-16/FOXO. By showing and evaluating genetic and biochemical interactions between DAF-16 and some of its essential cofactors and regulators, we gained important new insights into how DAF-16 is regulated and targets its downstream genes. Hopefully, this information provides new mechanistic avenues towards interventions against the aging process and resultant age-related diseases.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • de Haan, Gerald, Supervisor
    • Lansdorp, Peter, Supervisor
    • Riedel, Christian, Co-supervisor
    Award date22-Oct-2018
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-93019-85-0
    Electronic ISBNs978-94-034-1115-6
    Publication statusPublished - 2018

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