Next-generation nanoantibacterial tools developed from peptides

Renko de Vries, Cesar A. S. Andrade, Andris F. Bakuzis, Santi M. Mandal, Octavio L. Franco*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

6 Citations (Scopus)

Abstract

Bacteria resistant against various antimicrobial compounds have emerged in many countries, and the age of resistance has just started. Among the more promising novel antimicrobial compounds on which current research is focusing are the antimicrobial peptides (AMPs). These are often less susceptible to bacterial resistance since multiple modifications in the cellular membranes, cell wall and metabolism are required to reduce their effectiveness. Most likely, the use of pure AMPs will be insufficient for controlling pathogenic bacteria, and innovative approaches are required to employ AMPs in new antibiotic treatments. Therefore, here we review novel bionanotechnological approaches, including nanofibers, nanoparticles and magnetic particles for effectively using AMPs in fighting infectious diseases.

Original languageEnglish
Pages (from-to)1643-1661
Number of pages19
JournalNanomedicine
Volume10
Issue number10
DOIs
Publication statusPublished - 2015

Keywords

  • antimicrobial peptides
  • bacterial resistance
  • biofilms
  • magnetic particles
  • nanofibers
  • nanoparticles
  • SELF-ASSEMBLED MONOLAYERS
  • CELL-PENETRATING PEPTIDES
  • URINARY-TRACT-INFECTION
  • PROTEIN IMMOBILIZATION STRATEGIES
  • RESISTANT STAPHYLOCOCCUS-AUREUS
  • HUMAN IMMUNODEFICIENCY VIRUS
  • ESCHERICHIA-COLI STRAINS
  • AMIDE BOND FORMATION
  • IN-VIVO TRACKING
  • ANTIMICROBIAL PEPTIDES

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