Nocturnal non-invasive ventilation in addition to rehabilitation in hypercapnic patients with COPD

M.L. Duiverman, J.B. Wempe, G. Bladder, D.F. Jansen, H.A.M. Kerstjens, J.G. Zijlstra, P.J. Wijkstra

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Abstract

Background: Long-term non-invasive positive pressure ventilation (NIPPV) might improve the outcomes of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) with chronic respiratory failure. A study was undertaken to investigate whether nocturnal NIPPV in addition to pulmonary rehabilitation improves health-related quality of life, functional status and gas exchange compared with pulmonary rehabilitation alone in patients with COPD with chronic hypercapnic respiratory failure.

Methods: 72 patients with COPD were randomly assigned to nocturnal NIPPV in addition to rehabilitation (n = 37) or rehabilitation alone (n = 35). Outcome measures were assessed before and after the 3-month intervention period.

Results: The Chronic Respiratory Questionnaire total score improved 15.1 points with NIPPV + rehabilitation compared with 8.7 points with rehabilitation alone. The difference of 7.5 points was not significant (p = 0.08). However, compared with rehabilitation alone, the difference in the fatigue domain was greater with NIPPV + rehabilitation (mean difference 3.3 points, p

Conclusion: Non-invasive ventilation augments the benefits of pulmonary rehabilitation in patients with COPD with chronic hypercapnic respiratory failure as it improves several measures of health-related quality of life, functional status and gas exchange.

Original languageEnglish
Pages (from-to)1052-1057
Number of pages6
JournalThorax
Volume63
Issue number12
DOIs
Publication statusPublished - Dec-2008

Keywords

  • OBSTRUCTIVE PULMONARY-DISEASE
  • POSITIVE-PRESSURE VENTILATION
  • CHRONIC RESPIRATORY-FAILURE
  • QUALITY-OF-LIFE
  • RANDOMIZED CONTROLLED-TRIAL
  • CHRONIC LUNG-DISEASE
  • OXYGEN-THERAPY
  • MECHANICAL VENTILATION
  • STABLE COPD
  • EFFICACY

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