Non-human primates are essential models in the translational research of multiple sclerosis

Bert A. ‘t Hart; Che Serguera; Yolanda S. Kap; Bruno Gran

doi:10.1016/j.ddmod.2018.01.001

Non-human primates are essential models in the translational research of multiple sclerosis

Bert A. ‘t Hart^*, Che Serguera, Yolanda S. Kap, Bruno Gran

^*Corresponding author for this work

Molecular Neuroscience and Ageing Research (MOLAR)

Research output: Contribution to journal › Review article › peer-review

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Abstract

Ageing Western societies are facing an increasing prevalence of chronic inflammatory and degenerative diseases for which no effective treatments exist. The pressure on the drug development industry to develop such treatments creates a need for translationally relevant animal models, which faithfully replicate essential pathogenic mechanisms of the human disease. In this Short Review, we discuss the essential role of the non-human primate (NHP) in the translational research into the pathogenesis and treatment of the autoimmune neurological disease multiple sclerosis (MS).

Original language	English
Pages (from-to)	35-42
Number of pages	8
Journal	Drug Discovery Today: Disease Models
Volume	23
DOIs	https://doi.org/10.1016/j.ddmod.2018.01.001
Publication status	Published - 1-Mar-2017

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Non-human primates are essential models in the translational research of multiplesclerosisFinal publisher's version, 1.37 MBLicence: Taverne

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title = "Non-human primates are essential models in the translational research of multiple sclerosis",

abstract = "Ageing Western societies are facing an increasing prevalence of chronic inflammatory and degenerative diseases for which no effective treatments exist. The pressure on the drug development industry to develop such treatments creates a need for translationally relevant animal models, which faithfully replicate essential pathogenic mechanisms of the human disease. In this Short Review, we discuss the essential role of the non-human primate (NHP) in the translational research into the pathogenesis and treatment of the autoimmune neurological disease multiple sclerosis (MS).",

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AU - ‘t Hart, Bert A.

AU - Serguera, Che

AU - Kap, Yolanda S.

AU - Gran, Bruno

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AB - Ageing Western societies are facing an increasing prevalence of chronic inflammatory and degenerative diseases for which no effective treatments exist. The pressure on the drug development industry to develop such treatments creates a need for translationally relevant animal models, which faithfully replicate essential pathogenic mechanisms of the human disease. In this Short Review, we discuss the essential role of the non-human primate (NHP) in the translational research into the pathogenesis and treatment of the autoimmune neurological disease multiple sclerosis (MS).

U2 - 10.1016/j.ddmod.2018.01.001

DO - 10.1016/j.ddmod.2018.01.001

M3 - Review article

AN - SCOPUS:85041569049

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VL - 23

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EP - 42

JO - Drug Discovery Today: Disease Models

JF - Drug Discovery Today: Disease Models

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Non-human primates are essential models in the translational research of multiple sclerosis

Abstract

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