Non-invasive estimation of hepatic glucose uptake from [F-18]FDG PET images using tissue-derived input functions

N. Kudomi*, M. J. Jarvisalo, J. Kiss, R. Borra, A. Viljanen, T. Viljanen, T. Savunen, J. Knuuti, H. Iida, P. Nuutila, P. Iozzo

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    21 Citations (Scopus)

    Abstract

    The liver is perfused through the portal vein and hepatic artery. Quantification of hepatic glucose uptake (HGU) using PET requires the use of an input function for both the hepatic artery and portal vein. The former can be generally obtained invasively, but blood withdrawal from the portal vein is not practical in humans. The aim of this study was to develop and validate a new technique to obtain quantitative HGU by estimating the input function from PET images.

    Normal pigs (n = 12) were studied with [F-18]FDG PET, in which arterial and portal blood time-activity curves (TAC) were determined invasively to serve as reference measurements. The present technique consisted of two characteristics, i.e. using a model input function and simultaneously fitting multiple liver tissue TACs from images by minimizing the residual sum of square between the tissue TACs and fitted curves. The input function was obtained from the parameters determined from the fitting. The HGU values were computed by the estimated and measured input functions and compared between the methods.

    The estimated input functions were well reproduced. The HGU values, ranging from 0.005 to 0.02 ml/min per ml, were not significantly different between the two methods (r = 0.95, p <0.001). A Bland-Altman plot demonstrated a small overestimation by the image-derived method with a bias of 0.00052 ml/min per g for HGU.

    The results presented demonstrate that the input function can be estimated directly from the PET image, supporting the fully non-invasive assessment of liver glucose metabolism in human studies.

    Original languageEnglish
    Pages (from-to)2014-2026
    Number of pages13
    JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
    Volume36
    Issue number12
    DOIs
    Publication statusPublished - Dec-2009

    Keywords

    • [F-18]FDG PET
    • [F-18]FDG uptake kinetic modelling
    • Hepatic glucose uptake
    • Non-invasive
    • Input function
    • POSITRON-EMISSION-TOMOGRAPHY
    • BLOOD-FLOW MEASUREMENT
    • INDEPENDENT COMPONENT ANALYSIS
    • BRAIN TRANSFER CONSTANTS
    • TIME UPTAKE DATA
    • GRAPHICAL EVALUATION
    • F-18-FDG PET
    • INSULIN
    • LIVER
    • MODEL

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