Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours

Pepijn J P van der Aa; Max J H Witjes; Bert van der Vegt; Ed Schuuring; Koos Boeve; Grigory Sidorenkov; Geertruida H de Bock; Sebastiaan A H J de Visscher

doi:10.1111/odi.15235

Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours

Pepijn J P van der Aa, Max J H Witjes, Bert van der Vegt, Ed Schuuring, Koos Boeve, Grigory Sidorenkov, Geertruida H de Bock, Sebastiaan A H J de Visscher^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: This study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non-smoking, non-drinking (NSND) versus smoking and/or drinking (SD).

MATERIALS AND METHODS: Newly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).

RESULTS: 185 patients were included, and 32.4% of patients were NSND; this group represented an older (69 vs. 64.4 years, p < 0.01) and more female-dominated (66.7% vs. 44.5%, p = 0.02) population. NSND patients had more tongue tumours (68.3% vs. 46.4%, p < 0.01) and few floor-of-mouth tumours (1.7% vs. 20.0%, p < 0.01). Locoregional recurrence, overall survival and disease-specific survival risk were similar between the NSND and SD patients. NSND patients had a higher second primary tumour risk compared to SD patients in the multivariable analysis (adjusted HR 3.92, 1.23-12.48, p = 0.02).

CONCLUSION: NSND patients with OSCC have a distinct clinicopathological profile compared to SD patients, with a higher risk of second primary tumours after treatment. These differences in risk profiles should be considered in future OSCC management strategies.

Original language	English
Number of pages	10
Journal	Oral diseases
DOIs	https://doi.org/10.1111/odi.15235
Publication status	E-pub ahead of print - 30-Dec-2024

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@article{8645cfa5d1d1435bac2bfa1cc936e248,

title = "Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours",

abstract = "OBJECTIVES: This study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non-smoking, non-drinking (NSND) versus smoking and/or drinking (SD).MATERIALS AND METHODS: Newly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).RESULTS: 185 patients were included, and 32.4% of patients were NSND; this group represented an older (69 vs. 64.4 years, p < 0.01) and more female-dominated (66.7% vs. 44.5%, p = 0.02) population. NSND patients had more tongue tumours (68.3% vs. 46.4%, p < 0.01) and few floor-of-mouth tumours (1.7% vs. 20.0%, p < 0.01). Locoregional recurrence, overall survival and disease-specific survival risk were similar between the NSND and SD patients. NSND patients had a higher second primary tumour risk compared to SD patients in the multivariable analysis (adjusted HR 3.92, 1.23-12.48, p = 0.02).CONCLUSION: NSND patients with OSCC have a distinct clinicopathological profile compared to SD patients, with a higher risk of second primary tumours after treatment. These differences in risk profiles should be considered in future OSCC management strategies.",

author = "{van der Aa}, {Pepijn J P} and Witjes, {Max J H} and {van der Vegt}, Bert and Ed Schuuring and Koos Boeve and Grigory Sidorenkov and {de Bock}, {Geertruida H} and {de Visscher}, {Sebastiaan A H J}",

note = "{\textcopyright} 2024 The Author(s). Oral Diseases published by John Wiley & Sons Ltd.",

year = "2024",

month = dec,

day = "30",

doi = "10.1111/odi.15235",

language = "English",

journal = "Oral diseases",

issn = "1354-523X",

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T1 - Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours

AU - van der Aa, Pepijn J P

AU - Witjes, Max J H

AU - van der Vegt, Bert

AU - Schuuring, Ed

AU - Boeve, Koos

AU - Sidorenkov, Grigory

AU - de Bock, Geertruida H

AU - de Visscher, Sebastiaan A H J

PY - 2024/12/30

Y1 - 2024/12/30

N2 - OBJECTIVES: This study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non-smoking, non-drinking (NSND) versus smoking and/or drinking (SD).MATERIALS AND METHODS: Newly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).RESULTS: 185 patients were included, and 32.4% of patients were NSND; this group represented an older (69 vs. 64.4 years, p < 0.01) and more female-dominated (66.7% vs. 44.5%, p = 0.02) population. NSND patients had more tongue tumours (68.3% vs. 46.4%, p < 0.01) and few floor-of-mouth tumours (1.7% vs. 20.0%, p < 0.01). Locoregional recurrence, overall survival and disease-specific survival risk were similar between the NSND and SD patients. NSND patients had a higher second primary tumour risk compared to SD patients in the multivariable analysis (adjusted HR 3.92, 1.23-12.48, p = 0.02).CONCLUSION: NSND patients with OSCC have a distinct clinicopathological profile compared to SD patients, with a higher risk of second primary tumours after treatment. These differences in risk profiles should be considered in future OSCC management strategies.

AB - OBJECTIVES: This study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non-smoking, non-drinking (NSND) versus smoking and/or drinking (SD).MATERIALS AND METHODS: Newly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).RESULTS: 185 patients were included, and 32.4% of patients were NSND; this group represented an older (69 vs. 64.4 years, p < 0.01) and more female-dominated (66.7% vs. 44.5%, p = 0.02) population. NSND patients had more tongue tumours (68.3% vs. 46.4%, p < 0.01) and few floor-of-mouth tumours (1.7% vs. 20.0%, p < 0.01). Locoregional recurrence, overall survival and disease-specific survival risk were similar between the NSND and SD patients. NSND patients had a higher second primary tumour risk compared to SD patients in the multivariable analysis (adjusted HR 3.92, 1.23-12.48, p = 0.02).CONCLUSION: NSND patients with OSCC have a distinct clinicopathological profile compared to SD patients, with a higher risk of second primary tumours after treatment. These differences in risk profiles should be considered in future OSCC management strategies.

U2 - 10.1111/odi.15235

DO - 10.1111/odi.15235

M3 - Article

C2 - 39737774

SN - 1354-523X

JO - Oral diseases

JF - Oral diseases

ER -

Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours

Abstract

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