Abstract
Purpose: To evaluate in-phase and out-of-phase magnetic resonance (MR) imaging in the estimation of liver fat content (LFC) in patients with nonalcoholic fatty liver disease (NAFLD), with hydrogen (H-1) MR spectroscopy as the reference standard.
Materials and Methods: Written informed consent was obtained from all subjects, and the local ethics committee approved this prospective study protocol. A total of 33 patients with type 2 diabetes mellitus who were at high risk for NAFLD (23 men, 10 women; overall mean age, 62.8 years +/- .3 [standard deviation]; age range, 48-77 years) underwent 1.5-T MR imaging with H-1 MR spectroscopy and in-phase and out-of-phase imaging of the liver. Three fat indexes were calculated from the signal intensity (SI) measured on the images. Two radiologists independently graded SI changes between in-phase and out-of-phase images by means of visual inspection. The Pearson correlation coefficient was used to study the relationship between the obtained parameters of SI change and LFC measured with H-1 MR spectroscopy.
Results: Fat indexes calculated from in-phase and out-of-phase images correlated linearly with LFC measured with H-1 MR spectroscopy (P
Conclusion: In-phase and out-of-phase imaging can be used to rapidly estimate the LFC in patients with NAFLD. The cutoff value of 5.1% enables objective rapid and reliable discrimination of normal LFC from elevated LFC. (C) RSNA, 2008
| Original language | English |
|---|---|
| Pages (from-to) | 130-136 |
| Number of pages | 7 |
| Journal | Radiology |
| Volume | 250 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan-2009 |
Keywords
- MAGNETIC-RESONANCE-SPECTROSCOPY
- HEPATIC TRIGLYCERIDE CONTENT
- GENERAL-POPULATION
- INSULIN-RESISTANCE
- IRON OVERLOAD
- GRADIENT-ECHO
- RISK-FACTORS
- QUANTIFICATION
- STEATOSIS
- STEATOHEPATITIS