Abstract
Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent respiratory diseases characterized by airway inflammation, airway obstruction and airway hyperresponsiveness. Whilst current therapies, such as beta-agonists and glucocorticoids, may be effective at reducing symptoms, they do not reduce disease progression. Thus, there is a need to identify new therapeutic targets. In this review, we summarize the potential of novel targets or tools, including anti-inflammatories, phosphodiesterase inhibitors, kinase inhibitors, transient receptor potential channels, vitamin D and protease inhibitors, for the treatment of asthma and COPD. (C) 2014 Published by Elsevier Ltd.
Original language | English |
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Pages (from-to) | 181-198 |
Number of pages | 18 |
Journal | Pulmonary Pharmacology & Therapeutics |
Volume | 29 |
Issue number | 2 |
DOIs | |
Publication status | Published - Dec-2014 |
Keywords
- Therapeutic targets
- Kinase
- G-protein coupled receptor
- Transient receptor potential channel
- Inflammation
- Vitamin D
- OBSTRUCTIVE PULMONARY-DISEASE
- AIRWAY SMOOTH-MUSCLE
- ACTIVATED PROTEIN-KINASE
- PLACEBO-CONTROLLED TRIAL
- NECROSIS-FACTOR-ALPHA
- RANDOMIZED CONTROLLED-TRIAL
- ALLERGEN-INDUCED INFLAMMATION
- BETA-ADRENOCEPTOR AGONISTS
- POTENTIAL ANKYRIN-1 TRPA1
- VITAMIN-D SUPPLEMENTATION