Novel genes in renal aging

Gerda Anke Noordmans

    Research output: ThesisThesis fully internal (DIV)

    2050 Downloads (Pure)

    Abstract

    Renal aging is characterized by structural changes and functional decline. These changes make the elderly more vulnerable to chronic kidney disease, hypertension, and cardiovascular disease. Furthermore, they also make it more difficult to cope with stress factors, such as dehydration, toxicity, and obstruction. These stress factors can lead to acute kidney injury and reduced recovery from acute kidney injury and may result in chronic kidney disease or even end-stage renal disease. The rate of renal aging is influenced by environmental factors and lifestyle. In addition, several studies have provided evidence for the involvement of genetic background in the development of renal disease. Genetic variation plays an important role in the differentiation between people at risk for accelerated renal aging and might explain why one-third of the aging population shows no functional decline.
    In this thesis, several histological changes observed during renal aging have been analyzed in aged mice. Subsequently the associated genomic regions or candidate genes were identified and functionally investigated. We have identified candidate genes associated with age-related mesangial matrix expansion, perivascular immune-cell clusters and glomerular lipoprotein deposits. The data presented may lead to a better understanding of the processes and pathways involved in renal aging and lead to identification of individuals at risk or even allow us to design therapeutic strategies that can delay renal aging.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • van Goor, Harry, Supervisor
    • Hillebrands, Jan-Luuk, Supervisor
    • Heeringa, Peter, Supervisor
    • Korstanje, Ronny, Co-supervisor
    Award date21-Sept-2015
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-90-367-7998-2
    Electronic ISBNs978-90-367-7997-5
    Publication statusPublished - 2015

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