Novel inhibitors of aspartate transcarbamoylase (atcase) and compositions, methods and uses related thereto

Matthew Robert Groves; Chao Wang; Sergey Lunev; Bidong Zhang; Alexander Stephan Siegfried Dömling; Alida Visser

Novel inhibitors of aspartate transcarbamoylase (atcase) and compositions, methods and uses related thereto

Matthew Robert Groves (Inventor), Chao Wang (Inventor), Sergey Lunev (Inventor), Bidong Zhang (Inventor), Alexander Stephan Siegfried Dömling (Inventor), Alida Visser (Inventor)

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Abstract

The invention relates to inhibitors of Aspartate Transcarbamoylase (ATCase) and compositions, methods and uses related thereto, such as the treatment of malaria, tuberculosis and proliferative diseases, e.g. cancer. Provided is an ATCase inhibitor compound of the Formula I or a pharmaceutically acceptable salt, solvent or hydrate thereof.

Original language	English
Patent number	WO2023101556
Priority date	02/12/2021
Filing date	02/12/2022
Publication status	Published - 8-Jun-2023

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title = "Novel inhibitors of aspartate transcarbamoylase (atcase) and compositions, methods and uses related thereto",

abstract = "The invention relates to inhibitors of Aspartate Transcarbamoylase (ATCase) and compositions, methods and uses related thereto, such as the treatment of malaria, tuberculosis and proliferative diseases, e.g. cancer. Provided is an ATCase inhibitor compound of the Formula I or a pharmaceutically acceptable salt, solvent or hydrate thereof.",

author = "Groves, {Matthew Robert} and Chao Wang and Sergey Lunev and Bidong Zhang and D{\"o}mling, {Alexander Stephan Siegfried} and Alida Visser",

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type = "Patent",

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T1 - Novel inhibitors of aspartate transcarbamoylase (atcase) and compositions, methods and uses related thereto

AU - Groves, Matthew Robert

AU - Wang, Chao

AU - Lunev, Sergey

AU - Zhang, Bidong

AU - Dömling, Alexander Stephan Siegfried

AU - Visser, Alida

PY - 2023/6/8

Y1 - 2023/6/8

N2 - The invention relates to inhibitors of Aspartate Transcarbamoylase (ATCase) and compositions, methods and uses related thereto, such as the treatment of malaria, tuberculosis and proliferative diseases, e.g. cancer. Provided is an ATCase inhibitor compound of the Formula I or a pharmaceutically acceptable salt, solvent or hydrate thereof.

AB - The invention relates to inhibitors of Aspartate Transcarbamoylase (ATCase) and compositions, methods and uses related thereto, such as the treatment of malaria, tuberculosis and proliferative diseases, e.g. cancer. Provided is an ATCase inhibitor compound of the Formula I or a pharmaceutically acceptable salt, solvent or hydrate thereof.

M3 - Patent

M1 - WO2023101556

Y2 - 2022/12/02

ER -

Novel inhibitors of aspartate transcarbamoylase (atcase) and compositions, methods and uses related thereto

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