Novel molecular targets in hepatic stellate cells for the treatment of liver fibrosis

Natalia Smith Cortínez

    Research output: ThesisThesis fully internal (DIV)

    591 Downloads (Pure)

    Abstract

    Liver fibrosis is the result of chronic liver diseases that lead to cell death and scarring due to extracellular matrix (ECM) deposition. Hepatic stellate cells (HSC) are myofibroblast-like cells that activate upon injury and produce ECM. HSC activation, from quiescent HSC (qHSC) to activated HSC (aHSC) is controlled by the pro-fibrogenic cytokine transforming growth factor-beta (TGFβ) and regulates the production of alpha-smooth muscle actin (αSMA) and collagen-I, key markers of aHSC. aHSC contribute to the progression of liver fibrosis, so finding novel drugs that prevent or reverse the activation of HSC is an important step in developing effective treatments for liver fibrosis. We investigated the contribution of mitochondrial metabolism towards HSC activation and in Chapter 2 and Chapter 3, we targeted metabolic pathways that are involved in HSC activation. Excessive ECM deposition is the process that ultimately causes the scarring of the liver causing cirrhosis. Thus, we studied the molecular mechanisms driving collagen-I export in Chapter 4 and Chapter 5, targeted key proteins in this pathway to find novel targets to treat liver fibrosis.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    Supervisors/Advisors
    • Faber, Klaas Nico, Supervisor
    • Moshage, Han, Supervisor
    • Bultynck, Geert, Assessment committee, External person
    • Poelstra, Klaas, Assessment committee
    • van Ijzendoorn, Sven, Assessment committee
    Award date7-Jul-2020
    Place of Publication[Groningen]
    Publisher
    Print ISBNs978-94-6375-964-9
    Electronic ISBNs978-94-6375-968-7
    DOIs
    Publication statusPublished - 2020

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