Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy

Nasser A. M. Yehia; Walfrido Antuch; Barbara Beck; Sibylle Hess; Vesna Schauer-Vukašinović; Michael Almstetter; Patrick Furer; Eberhardt Herdtweck; Alexander Dömling

doi:10.1016/j.bmcl.2004.04.026

Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy

Nasser A. M. Yehia, Walfrido Antuch, Barbara Beck, Sibylle Hess, Vesna Schauer-Vukašinović, Michael Almstetter, Patrick Furer, Eberhardt Herdtweck, Alexander Dömling

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Abstract

Using a newly developed multicomponent chemistry strategy in combination with structure based drug design, a new class of HIV-1 protease inhibitors has been obtained. © 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	3121-3125
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2004.04.026
Publication status	Published - 21-Jun-2004

Keywords

AIDS
HIV
Inhibitor
Isocyanide
MCR
Protease
proteinase inhibitor
acquired immune deficiency syndrome
article
drug design
drug structure
drug synthesis
X ray analysis

Access to Document

10.1016/j.bmcl.2004.04.026

Cite this

Yehia, Nasser A. M. ; Antuch, Walfrido ; Beck, Barbara ; Hess, Sibylle ; Schauer-Vukašinović, Vesna ; Almstetter, Michael ; Furer, Patrick ; Herdtweck, Eberhardt ; Dömling, Alexander. / Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 12. pp. 3121-3125.

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abstract = "Using a newly developed multicomponent chemistry strategy in combination with structure based drug design, a new class of HIV-1 protease inhibitors has been obtained. {\textcopyright} 2004 Elsevier Ltd. All rights reserved.",

keywords = "AIDS, HIV, Inhibitor, Isocyanide, MCR, Protease, proteinase inhibitor, acquired immune deficiency syndrome, article, drug design, drug structure, drug synthesis, X ray analysis",

author = "Yehia, {Nasser A. M.} and Walfrido Antuch and Barbara Beck and Sibylle Hess and Vesna Schauer-Vuka{\v s}inovi{\'c} and Michael Almstetter and Patrick Furer and Eberhardt Herdtweck and Alexander D{\"o}mling",

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Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy. / Yehia, Nasser A. M.; Antuch, Walfrido; Beck, Barbara; Hess, Sibylle; Schauer-Vukašinović, Vesna; Almstetter, Michael; Furer, Patrick; Herdtweck, Eberhardt; Dömling, Alexander.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 12, 21.06.2004, p. 3121-3125.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Antuch, Walfrido

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AU - Hess, Sibylle

AU - Schauer-Vukašinović, Vesna

AU - Almstetter, Michael

AU - Furer, Patrick

AU - Herdtweck, Eberhardt

AU - Dömling, Alexander

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KW - HIV

KW - Inhibitor

KW - Isocyanide

KW - MCR

KW - Protease

KW - proteinase inhibitor

KW - acquired immune deficiency syndrome

KW - article

KW - drug design

KW - drug structure

KW - drug synthesis

KW - X ray analysis

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