Novel nonpeptidic inhibitors of HIV-1 protease obtained via a new multicomponent chemistry strategy

Nasser A. M. Yehia, Walfrido Antuch, Barbara Beck, Sibylle Hess, Vesna Schauer-Vukašinović, Michael Almstetter, Patrick Furer, Eberhardt Herdtweck, Alexander Dömling

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Using a newly developed multicomponent chemistry strategy in combination with structure based drug design, a new class of HIV-1 protease inhibitors has been obtained. © 2004 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)3121-3125
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number12
Publication statusPublished - 21-Jun-2004


  • AIDS
  • HIV
  • Inhibitor
  • Isocyanide
  • MCR
  • Protease
  • proteinase inhibitor
  • acquired immune deficiency syndrome
  • article
  • drug design
  • drug structure
  • drug synthesis
  • X ray analysis

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