Novel organization of the arginine catabolic mobile element and staphylococcal cassette chromosome mec composite island and its horizontal transfer between distinct Staphylococcus aureus genotypes

Artur J Sabat; Robin Köck; Viktoria Akkerboom; Ron Hendrix; Robert L Skov; Karsten Becker; Alexander W Friedrich

doi:10.1128/AAC.01321-13

Novel organization of the arginine catabolic mobile element and staphylococcal cassette chromosome mec composite island and its horizontal transfer between distinct Staphylococcus aureus genotypes

Artur J Sabat, Robin Köck, Viktoria Akkerboom, Ron Hendrix, Robert L Skov, Karsten Becker, Alexander W Friedrich

Microbes in Health and Disease (MHD)

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

In this study, 425 methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered in the Dutch-German Euregio were investigated for the presence of the arginine catabolic mobile element (ACME). Sequence analysis by whole-genome sequencing revealed an entirely new organization of the ACME-staphylococcal cassette chromosome mec composite island (SCCmec-CI), with truncated ACME type II located downstream of SCCmec. An identical nucleotide sequence of ACME-SCCmec-CI was found in two distinct MRSA lineages (t064-ST8 and t002-ST5), which has not been reported previously in S. aureus.

Original language	English
Pages (from-to)	5774-5777
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	11
DOIs	https://doi.org/10.1128/AAC.01321-13
Publication status	Published - Nov-2013

Keywords

METHICILLIN-RESISTANT
USA300
SEQUENCE
VIRULENCE
EPIDERMIDIS
CARRIAGE
VARIANT
CLONE

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Sabat, A. J., Köck, R., Akkerboom, V., Hendrix, R., Skov, R. L., Becker, K., & Friedrich, A. W. (2013). Novel organization of the arginine catabolic mobile element and staphylococcal cassette chromosome mec composite island and its horizontal transfer between distinct Staphylococcus aureus genotypes. Antimicrobial Agents and Chemotherapy, 57(11), 5774-5777. https://doi.org/10.1128/AAC.01321-13

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title = "Novel organization of the arginine catabolic mobile element and staphylococcal cassette chromosome mec composite island and its horizontal transfer between distinct Staphylococcus aureus genotypes",

abstract = "In this study, 425 methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered in the Dutch-German Euregio were investigated for the presence of the arginine catabolic mobile element (ACME). Sequence analysis by whole-genome sequencing revealed an entirely new organization of the ACME-staphylococcal cassette chromosome mec composite island (SCCmec-CI), with truncated ACME type II located downstream of SCCmec. An identical nucleotide sequence of ACME-SCCmec-CI was found in two distinct MRSA lineages (t064-ST8 and t002-ST5), which has not been reported previously in S. aureus.",

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author = "Sabat, {Artur J} and Robin K{\"o}ck and Viktoria Akkerboom and Ron Hendrix and Skov, {Robert L} and Karsten Becker and Friedrich, {Alexander W}",

year = "2013",

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Sabat, AJ, Köck, R, Akkerboom, V, Hendrix, R, Skov, RL, Becker, K & Friedrich, AW 2013, 'Novel organization of the arginine catabolic mobile element and staphylococcal cassette chromosome mec composite island and its horizontal transfer between distinct Staphylococcus aureus genotypes', Antimicrobial Agents and Chemotherapy, vol. 57, no. 11, pp. 5774-5777. https://doi.org/10.1128/AAC.01321-13

Novel organization of the arginine catabolic mobile element and staphylococcal cassette chromosome mec composite island and its horizontal transfer between distinct Staphylococcus aureus genotypes. / Sabat, Artur J; Köck, Robin; Akkerboom, Viktoria et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 57, No. 11, 11.2013, p. 5774-5777.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Novel organization of the arginine catabolic mobile element and staphylococcal cassette chromosome mec composite island and its horizontal transfer between distinct Staphylococcus aureus genotypes

AU - Sabat, Artur J

AU - Köck, Robin

AU - Akkerboom, Viktoria

AU - Hendrix, Ron

AU - Skov, Robert L

AU - Becker, Karsten

AU - Friedrich, Alexander W

PY - 2013/11

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AB - In this study, 425 methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered in the Dutch-German Euregio were investigated for the presence of the arginine catabolic mobile element (ACME). Sequence analysis by whole-genome sequencing revealed an entirely new organization of the ACME-staphylococcal cassette chromosome mec composite island (SCCmec-CI), with truncated ACME type II located downstream of SCCmec. An identical nucleotide sequence of ACME-SCCmec-CI was found in two distinct MRSA lineages (t064-ST8 and t002-ST5), which has not been reported previously in S. aureus.

KW - METHICILLIN-RESISTANT

KW - USA300

KW - SEQUENCE

KW - VIRULENCE

KW - EPIDERMIDIS

KW - CARRIAGE

KW - VARIANT

KW - CLONE

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DO - 10.1128/AAC.01321-13

M3 - Article

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SN - 0066-4804

VL - 57

SP - 5774

EP - 5777

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Novel organization of the arginine catabolic mobile element and staphylococcal cassette chromosome mec composite island and its horizontal transfer between distinct Staphylococcus aureus genotypes

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Keywords

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