Novel uric acid-based nano organocatalyst with phosphorous acid tags: Application for synthesis of new biologically-interest pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation

Sima Kalhor*, Mahmoud Zarei, Hassan Sepehrmansourie, Mohammad Ali Zolfigol, Hu Shi, Jinping Wang, Jalal Arjomandi, Masoumeh Hasani, Romana Schirhagl

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)
142 Downloads (Pure)

Abstract

In this study, we have designed, synthesized and full characterized a novel biological based acidic nano organocatalyst via condensations reaction of uric acid and phosphorous acid. The obtained compound was named theacrine tetrakis(phosphonic acid) (TTPA) and prepared under refluxing ethanol. This new nano organocatalyst was applied as an efficient and recyclable catalyst for the preparation of novel pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation with good to excellent yields.

Original languageEnglish
Article number111549
Number of pages16
JournalMolecular catalysis
Volume507
Early online date20-Apr-2021
DOIs
Publication statusPublished - May-2021

Keywords

  • (2-Methyl-1H-indol-3-yl)-pyrazolo[3,4-b]pyridine
  • Phosphorous acid
  • theacrine tetrakis (phosphonic acid) (TTPA)
  • Uric acid
  • Vinyligous anomeric based oxidation
  • IONIC LIQUID
  • EFFICIENT CATALYST
  • STRUCTURAL-CHARACTERIZATION
  • MOLTEN-SALT
  • GREEN
  • DERIVATIVES
  • GLYCOLURIL
  • COMPLEXES
  • DESIGN

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