Nuchal Skinfold Thickness: A Novel Parameter for Assessment of Body Composition in Childhood Craniopharyngioma

Anthe S. Sterkenburg; Anika Hoffmann; Julia Reichel; Kristin Lohle; Maria Eveslage; Monika Warmuth-Metz; Hermann L. Mueller

doi:10.1210/jc.2016-2547

Nuchal Skinfold Thickness: A Novel Parameter for Assessment of Body Composition in Childhood Craniopharyngioma

Anthe S. Sterkenburg
, Anika Hoffmann
, Julia Reichel
, Kristin Lohle
, Maria Eveslage
, Monika Warmuth-Metz
, Hermann L. Mueller^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

396 Downloads (Pure)

Abstract

Context: Hypothalamic obesity, cardiovascular disease (CVD), and relapse/progression have a major impact on prognosis in childhood-onset craniopharyngioma (CP). We analyzed nuchal skinfold thickness (NST) on magnetic resonance imaging performed for follow-up monitoring as a novel parameter for body composition (BC) and CVD in CP.

Objective: The objective of the study was to identify the association of NST with body mass index (BMI), waist to height ratio (WHtR), functional capacity, and blood pressure (BP) in CP and controls.

Design: This was a cross-sectional and longitudinal prospective study in CP patients.

Setting: The study was conducted at HIT-Endo, KRANIOPHARYNGEOM 2000/2007.

Patients: Participants included 94 CP patients and 75 controls.

Interventions: There were no interventions.

Main Outcome Measures: Association of NST with BC and BP in 43 CP and 43 controls was measured.

Results: NST correlated with BMI SD score (SDS; r = 0.78; P = .001; n = 169) and WHtR (r = 0.85; P = .001; n = 86) in the total cohort and CP patients (NST-BMI SDS: r = 0.77, P = .001, n = 94); NST-WHtR: r = 0.835, P = .001, n = 43) and controls (NST-BMI SDS: r = 0.792, P = .001, n = 75; NST-WHtR: r = 0.671, P = .001, n = 43). In CP, systolic BP correlated with NST (r = 0.575, P = .001), BMI SDS (r = 0.434, P = .004), and WHtR (r = 0.386, P = .011). Similar results were observed for diastolic BP in CP. In multivariate analyses, NST had a predictive value for hypertension in postpubertal CP and controls (odds ratio 6.98, 95% confidence interval [1.65, 29.5], P = .008). During a longitudinal follow-up, changes in NST correlated with changes in BMI SDS (P = .001) and WHtR (P = .01) but not with changes in BP and functional capacity.

Conclusions: Because monitoring of magnetic resonance imaging and BC is essential for follow-up in CP, NST could serve as a novel and clinically relevant parameter for longitudinal assessment of BC and CVD risk in CP.

Original language	English
Pages (from-to)	4922-4930
Number of pages	9
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	101
Issue number	12
DOIs	https://doi.org/10.1210/jc.2016-2547
Publication status	Published - Dec-2016
Externally published	Yes

Keywords

TO-HEIGHT RATIO
SUBCUTANEOUS ADIPOSE-TISSUE
DISEASE RISK-FACTORS
LONG-TERM SURVIVORS
QUALITY-OF-LIFE
MASS INDEX
NECK CIRCUMFERENCE
ONSET CRANIOPHARYNGIOMA
GERMAN MULTICENTER
VISCERAL ADIPOSITY

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@article{078d88758fd841e2b56d3a77b46ff454,

title = "Nuchal Skinfold Thickness: A Novel Parameter for Assessment of Body Composition in Childhood Craniopharyngioma",

abstract = "Context: Hypothalamic obesity, cardiovascular disease (CVD), and relapse/progression have a major impact on prognosis in childhood-onset craniopharyngioma (CP). We analyzed nuchal skinfold thickness (NST) on magnetic resonance imaging performed for follow-up monitoring as a novel parameter for body composition (BC) and CVD in CP.Objective: The objective of the study was to identify the association of NST with body mass index (BMI), waist to height ratio (WHtR), functional capacity, and blood pressure (BP) in CP and controls.Design: This was a cross-sectional and longitudinal prospective study in CP patients.Setting: The study was conducted at HIT-Endo, KRANIOPHARYNGEOM 2000/2007.Patients: Participants included 94 CP patients and 75 controls.Interventions: There were no interventions.Main Outcome Measures: Association of NST with BC and BP in 43 CP and 43 controls was measured.Results: NST correlated with BMI SD score (SDS; r = 0.78; P = .001; n = 169) and WHtR (r = 0.85; P = .001; n = 86) in the total cohort and CP patients (NST-BMI SDS: r = 0.77, P = .001, n = 94); NST-WHtR: r = 0.835, P = .001, n = 43) and controls (NST-BMI SDS: r = 0.792, P = .001, n = 75; NST-WHtR: r = 0.671, P = .001, n = 43). In CP, systolic BP correlated with NST (r = 0.575, P = .001), BMI SDS (r = 0.434, P = .004), and WHtR (r = 0.386, P = .011). Similar results were observed for diastolic BP in CP. In multivariate analyses, NST had a predictive value for hypertension in postpubertal CP and controls (odds ratio 6.98, 95\% confidence interval [1.65, 29.5], P = .008). During a longitudinal follow-up, changes in NST correlated with changes in BMI SDS (P = .001) and WHtR (P = .01) but not with changes in BP and functional capacity.Conclusions: Because monitoring of magnetic resonance imaging and BC is essential for follow-up in CP, NST could serve as a novel and clinically relevant parameter for longitudinal assessment of BC and CVD risk in CP.",

keywords = "TO-HEIGHT RATIO, SUBCUTANEOUS ADIPOSE-TISSUE, DISEASE RISK-FACTORS, LONG-TERM SURVIVORS, QUALITY-OF-LIFE, MASS INDEX, NECK CIRCUMFERENCE, ONSET CRANIOPHARYNGIOMA, GERMAN MULTICENTER, VISCERAL ADIPOSITY",

author = "Sterkenburg, \{Anthe S.\} and Anika Hoffmann and Julia Reichel and Kristin Lohle and Maria Eveslage and Monika Warmuth-Metz and Mueller, \{Hermann L.\}",

year = "2016",

month = dec,

doi = "10.1210/jc.2016-2547",

language = "English",

volume = "101",

pages = "4922--4930",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "Oxford University Press",

number = "12",

}

TY - JOUR

T1 - Nuchal Skinfold Thickness

T2 - A Novel Parameter for Assessment of Body Composition in Childhood Craniopharyngioma

AU - Sterkenburg, Anthe S.

AU - Hoffmann, Anika

AU - Reichel, Julia

AU - Lohle, Kristin

AU - Eveslage, Maria

AU - Warmuth-Metz, Monika

AU - Mueller, Hermann L.

PY - 2016/12

Y1 - 2016/12

N2 - Context: Hypothalamic obesity, cardiovascular disease (CVD), and relapse/progression have a major impact on prognosis in childhood-onset craniopharyngioma (CP). We analyzed nuchal skinfold thickness (NST) on magnetic resonance imaging performed for follow-up monitoring as a novel parameter for body composition (BC) and CVD in CP.Objective: The objective of the study was to identify the association of NST with body mass index (BMI), waist to height ratio (WHtR), functional capacity, and blood pressure (BP) in CP and controls.Design: This was a cross-sectional and longitudinal prospective study in CP patients.Setting: The study was conducted at HIT-Endo, KRANIOPHARYNGEOM 2000/2007.Patients: Participants included 94 CP patients and 75 controls.Interventions: There were no interventions.Main Outcome Measures: Association of NST with BC and BP in 43 CP and 43 controls was measured.Results: NST correlated with BMI SD score (SDS; r = 0.78; P = .001; n = 169) and WHtR (r = 0.85; P = .001; n = 86) in the total cohort and CP patients (NST-BMI SDS: r = 0.77, P = .001, n = 94); NST-WHtR: r = 0.835, P = .001, n = 43) and controls (NST-BMI SDS: r = 0.792, P = .001, n = 75; NST-WHtR: r = 0.671, P = .001, n = 43). In CP, systolic BP correlated with NST (r = 0.575, P = .001), BMI SDS (r = 0.434, P = .004), and WHtR (r = 0.386, P = .011). Similar results were observed for diastolic BP in CP. In multivariate analyses, NST had a predictive value for hypertension in postpubertal CP and controls (odds ratio 6.98, 95% confidence interval [1.65, 29.5], P = .008). During a longitudinal follow-up, changes in NST correlated with changes in BMI SDS (P = .001) and WHtR (P = .01) but not with changes in BP and functional capacity.Conclusions: Because monitoring of magnetic resonance imaging and BC is essential for follow-up in CP, NST could serve as a novel and clinically relevant parameter for longitudinal assessment of BC and CVD risk in CP.

AB - Context: Hypothalamic obesity, cardiovascular disease (CVD), and relapse/progression have a major impact on prognosis in childhood-onset craniopharyngioma (CP). We analyzed nuchal skinfold thickness (NST) on magnetic resonance imaging performed for follow-up monitoring as a novel parameter for body composition (BC) and CVD in CP.Objective: The objective of the study was to identify the association of NST with body mass index (BMI), waist to height ratio (WHtR), functional capacity, and blood pressure (BP) in CP and controls.Design: This was a cross-sectional and longitudinal prospective study in CP patients.Setting: The study was conducted at HIT-Endo, KRANIOPHARYNGEOM 2000/2007.Patients: Participants included 94 CP patients and 75 controls.Interventions: There were no interventions.Main Outcome Measures: Association of NST with BC and BP in 43 CP and 43 controls was measured.Results: NST correlated with BMI SD score (SDS; r = 0.78; P = .001; n = 169) and WHtR (r = 0.85; P = .001; n = 86) in the total cohort and CP patients (NST-BMI SDS: r = 0.77, P = .001, n = 94); NST-WHtR: r = 0.835, P = .001, n = 43) and controls (NST-BMI SDS: r = 0.792, P = .001, n = 75; NST-WHtR: r = 0.671, P = .001, n = 43). In CP, systolic BP correlated with NST (r = 0.575, P = .001), BMI SDS (r = 0.434, P = .004), and WHtR (r = 0.386, P = .011). Similar results were observed for diastolic BP in CP. In multivariate analyses, NST had a predictive value for hypertension in postpubertal CP and controls (odds ratio 6.98, 95% confidence interval [1.65, 29.5], P = .008). During a longitudinal follow-up, changes in NST correlated with changes in BMI SDS (P = .001) and WHtR (P = .01) but not with changes in BP and functional capacity.Conclusions: Because monitoring of magnetic resonance imaging and BC is essential for follow-up in CP, NST could serve as a novel and clinically relevant parameter for longitudinal assessment of BC and CVD risk in CP.

KW - TO-HEIGHT RATIO

KW - SUBCUTANEOUS ADIPOSE-TISSUE

KW - DISEASE RISK-FACTORS

KW - LONG-TERM SURVIVORS

KW - QUALITY-OF-LIFE

KW - MASS INDEX

KW - NECK CIRCUMFERENCE

KW - ONSET CRANIOPHARYNGIOMA

KW - GERMAN MULTICENTER

KW - VISCERAL ADIPOSITY

U2 - 10.1210/jc.2016-2547

DO - 10.1210/jc.2016-2547

M3 - Article

SN - 0021-972X

VL - 101

SP - 4922

EP - 4930

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 12

ER -

Nuchal Skinfold Thickness: A Novel Parameter for Assessment of Body Composition in Childhood Craniopharyngioma

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Keywords

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