Obesity and its impact on COVID-19

Angélica J M de Leeuw; Maureen A M Oude Luttikhuis; Annemarijn C Wellen; Christine Müller; Cornelis F Calkhoven

doi:10.1007/s00109-021-02072-4

Obesity and its impact on COVID-19

Angélica J M de Leeuw, Maureen A M Oude Luttikhuis, Annemarijn C Wellen, Christine Müller, Cornelis F Calkhoven^*

^*Corresponding author for this work

Stem Cell Aging Leukemia and Lymphoma (SALL)

Research output: Contribution to journal › Review article › peer-review

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Abstract

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.

Original language	English
Pages (from-to)	899-915
Number of pages	17
Journal	Journal of Molecular Medicine
Volume	99
Issue number	7
Early online date	6-Apr-2021
DOIs	https://doi.org/10.1007/s00109-021-02072-4
Publication status	Published - Jul-2021

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10.1007/s00109-021-02072-4Licence: CC BY

Obesity and its impact on COVID-19Final publisher's version, 17 MBLicence: CC BY

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title = "Obesity and its impact on COVID-19",

abstract = "The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.",

author = "{de Leeuw}, {Ang{\'e}lica J M} and {Oude Luttikhuis}, {Maureen A M} and Wellen, {Annemarijn C} and Christine M{\"u}ller and Calkhoven, {Cornelis F}",

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AU - de Leeuw, Angélica J M

AU - Oude Luttikhuis, Maureen A M

AU - Wellen, Annemarijn C

AU - Müller, Christine

AU - Calkhoven, Cornelis F

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AB - The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.

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