Obesity and its impact on COVID-19

Angélica J M de Leeuw; Maureen A M Oude Luttikhuis; Annemarijn C Wellen; Christine Müller; Cornelis F Calkhoven

doi:10.1007/s00109-021-02072-4

Obesity and its impact on COVID-19

Angélica J M de Leeuw
, Maureen A M Oude Luttikhuis
, Annemarijn C Wellen
, Christine Müller
, Cornelis F Calkhoven^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

69 Citations (Scopus)

131 Downloads (Pure)

Abstract

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.

Original language	English
Pages (from-to)	899-915
Number of pages	17
Journal	Journal of Molecular Medicine
Volume	99
Issue number	7
Early online date	6-Apr-2021
DOIs	https://doi.org/10.1007/s00109-021-02072-4
Publication status	Published - Jul-2021

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title = "Obesity and its impact on COVID-19",

abstract = "The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.",

author = "\{de Leeuw\}, \{Ang{\'e}lica J M\} and \{Oude Luttikhuis\}, \{Maureen A M\} and Wellen, \{Annemarijn C\} and Christine M{\"u}ller and Calkhoven, \{Cornelis F\}",

year = "2021",

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doi = "10.1007/s00109-021-02072-4",

language = "English",

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journal = "Journal of Molecular Medicine",

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T1 - Obesity and its impact on COVID-19

AU - de Leeuw, Angélica J M

AU - Oude Luttikhuis, Maureen A M

AU - Wellen, Annemarijn C

AU - Müller, Christine

AU - Calkhoven, Cornelis F

PY - 2021/7

Y1 - 2021/7

N2 - The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.

AB - The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.

U2 - 10.1007/s00109-021-02072-4

DO - 10.1007/s00109-021-02072-4

M3 - Review article

C2 - 33824998

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SP - 899

EP - 915

JO - Journal of Molecular Medicine

JF - Journal of Molecular Medicine

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ER -

Obesity and its impact on COVID-19

Abstract

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