Objective and subjective effects of treatment for testicular cancer on sexual function

JPA Van Basten, MF Van Driel*, HJ Hoekstra, DT Sleijfer, HBM Van de Wiel, JHJ Droste, HJA Mensink, H. Schraffordt Koops

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    28 Citations (Scopus)

    Abstract

    Objective To determine whether the treatment of patients with testicular cancer, using cisplatin combined with etoposide and bleomycin (BEP) after orchidectomy in those with disseminated disease, causes changes in sex hormones and penile vascularization, possibly related to sexual dysfunction,

    Patients and methods Ten patients treated with BEP were compared with 11 undergoing orchidectomy alone followed by surveillance. Sex hormone levels were analysed and cavernosal artery duplex ultrasonography performed before orchidectomy and at 6 and 12 months afterward. Patients were questioned about their sexual function. After 1 pear, a visual erotic stimulation (VES) test was performed to assess penile rigidity.

    Results In contrast to the surveillance group, BEP-treated patients had higher follicle-stimulating hormone (4.6 vs 26.5 U/L) and luteinizing hormone (1.4 vs 8.2 U/L) levels, and lower testosterone levels (21.1 vs 14.7 nmol/L) at 6 months than at baseline. At 1 year, most patients had compensated hypergonadotrophic. eugonadism, but Leydig cell function had recovered. Changes in cavernosal artery peak flow velocities induced by local injection with papaverine/phentolamine showed no difference between the groups before and 6 months after orchidectomy. Loss of libido and erectile dysfunction were reported more frequently by BEP-treated patients, However, 1 year after treatment, most reported a satisfying sex life and VES resulted in a rigid erection in nearly all patients. The reported erectile dysfunction could not be explained by changes in plasma testosterone levels or diminished blood flow velocities,

    Conclusions After being diagnosed with testicular cancer, sexual morbidity is considerable, but within 1 year some improvement may be expected. BEP induces transient testicular dysfunction but this recovers. Although BEP is related to symptoms of angiopathy, cavernosal blood flow seems to be unaffected. These findings and the normal VES-evoked penile rigidity suggest that sexual dysfunction is more psychological than organically induced by BEP.

    Original languageEnglish
    Pages (from-to)671-678
    Number of pages8
    JournalBJU International
    Volume84
    Issue number6
    Publication statusPublished - Oct-1999

    Keywords

    • testicular cancer
    • chemotherapy
    • hormones
    • angiopathy
    • sexual function
    • CISPLATIN-BASED CHEMOTHERAPY
    • GERM-CELL CANCER
    • FERTILITY
    • BLEOMYCIN
    • TESTOSTERONE
    • VINBLASTINE
    • ERECTION
    • TUMORS
    • MEN

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