On-demand antimicrobial release from a temperature-sensitive polymer - Comparison with ad libitum release from central venous catheters

Jelmer Sjollema*, Rene J.B. Dijkstra, Caroline Abeln, Henderina van der Mei, Dirk Van Asseldonk, Hendrik Busscher

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Antimicrobial releasing biomaterial coatings have found application for instance in the fixation of orthopedic joint prostheses and central venous catheters. Most frequently, the release kinetics is such that antimicrobially-effective concentrations are only reached within the first days to weeks after implantation, leaving no local antimicrobial release available when a biomaterial-associated infection occurs later. Here we compare the ad libitum release of chlorhexidine and silver-sulfadiazine from a central venous catheter with their release from a new, on-demand release coating consisting of a temperature-sensitive copolymer of styrene and n-butyl (meth)acrylate. The copolymer can be loaded with an antimicrobial, which is released when the temperature is raised above its glass transition temperature. Ad libitum release of chlorhexidine and silver-sulfadiazine from a commercially-purchased catheter and associated antimicrobial efficacy against Staphylococcus aureus was limited to 16 days. Consecutive temperature-triggers of our on-demand coating yielded little or no antimicrobial efficacy of silver-acetate release, but antimicrobially-effective chlorhexidine concentrations were observed over a time period of 60-80 days. This attests to the clear advantage of on-demand coatings above ad libitum releasing coatings, that may have released their antimicrobial content before it is actually needed. Importantly, glass transition temperature of chlorhexidine loaded copolymers was lower (48 °C) than of silver loaded ones (61 °C), facilitating their clinical use. © 2014 Elsevier B.V.
Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalJournal of Controlled Release
Volume188
DOIs
Publication statusPublished - 28-Aug-2014

Keywords

  • Biofilms
  • Central venous catheters
  • Chlorhexidine
  • Infection
  • Silver
  • chlorhexidine
  • styrene
  • sulfadiazine silver
  • antimicrobial catheter
  • article
  • central venous catheter
  • comparative study
  • concentration response
  • controlled drug release
  • controlled study
  • drug coating
  • drug release
  • glass transition temperature
  • heat sensitivity
  • high temperature
  • nonhuman
  • priority journal
  • Staphylococcus aureus

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