On the methods of studying protein-ligand interaction dynamics

A function of any biomolecule is inevitably connected to its dynamics. Structural biology enables understanding of this function through changes in biomolecule's structure. In turn, changes in protein structure (for example, trigged by a binding of designed small molecules to the protein of interest), can have functional effects, that would prompt a desired therapeutic effect.
In this thesis, I shed some light on both obtaining transient structures of membrane proteins and using protein structures for drug discovery. I hope that my findings will be useful for researchers interested in drug development and will contribute into optimization of drug-development pipelines.