One pot 'click' reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition

Lachlan S. Campbell-Verduyn, Wiktor Szymanski, Christiaan P. Postema, Rudi A. Dierckx, Philip H. Elsinga*, Dick B. Janssen, Ben L. Feringa

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Halohydrin dehalogenase (HheC) can perform enantioselective azidolysis of aromatic epoxides to 1,2-azido alcohols which are subsequently ligated to alkynes producing chiral hydroxy triazoles in a one-pot procedure with excellent enantiomeric excess.

Original languageEnglish
Pages (from-to)898-900
Number of pages3
JournalChemical Communications
Volume46
Issue number6
DOIs
Publication statusPublished - 2010

Keywords

  • COPPER-FREE CLICK
  • 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES
  • HALOHYDRIN DEHALOGENASE
  • TERMINAL ALKYNES
  • CHEMISTRY
  • CONVERSION

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