Abstract
A one-pot total synthesis of aspergillamide and analogues by a solution phase Ugi multi component reaction (MCR) is described. The reaction is easily performed in 96-well plates and offers a facile access to diverse aspergillamide analogue compound libraries. The antibiotic and cytotoxic activity of these compounds is measured. Several of them are more potent than the natural product. (C) 2000 Elsevier Science Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 1701-1705 |
| Number of pages | 5 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 10 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 7-Aug-2000 |
Keywords
- amide
- aspergillamide
- drug analog
- unclassified drug
- antibacterial activity
- antifungal activity
- article
- Bacillus subtilis
- Candida albicans
- cell proliferation
- drug inhibition
- drug screening
- drug synthesis
- nonhuman
- Pseudomonas aeruginosa
- Staphylococcus aureus
- tumor cell line