One-pot synthesis of 2-amino-indole-3-carboxamide and analogous

Kan Wang, Eberhardt Herdtweck, Alexander Dömling

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)


An efficient one-pot, two-step solution-phase synthetic method was developed to synthesize twenty-three 2-amino-indole-3-carboxamides (3) from 2-halonitrobenzene (1) or heterocyclic analogous and cyanoacetamides (2). In this sequence, first, intermediate 2-cyano-2-(2-nitrophenyl)acetamide (4) was generated under basic condition via S(NAr) reaction; after direct addition of hydrochloric acid solution, FeCl(3), and Zn powder, indole 3 was generated via reduction/cyclization process.

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalAcs combinatorial science
Issue number2
Publication statusPublished - 14-Mar-2011
Externally publishedYes


  • Aminoimidazole Carboxamide
  • Indoles
  • Models, Molecular
  • Molecular Structure
  • Nitrobenzenes

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