One-pot synthesis of 6-l-[18f] fluoro-3,4-dihydroxyphenylalanine (6-l-[18f] fdopa).

Geert Luurtsema; Chantal Kwizera; Simon Niels Blok; Ines  Farinha Antunes; Philippus Hein Elsinga; Erik de Vries

One-pot synthesis of 6-l-[18f] fluoro-3,4-dihydroxyphenylalanine (6-l-[18f] fdopa).

Geert Luurtsema (Inventor), Chantal Kwizera (Inventor), Simon Niels Blok (Inventor), Ines Farinha Antunes (Inventor), Philippus Hein Elsinga (Inventor), Erik de Vries (Inventor)

Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)

Research output: Patent

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Abstract

The invention relates to the field of medicinal chemistry and radiopharmaceuticals, in particular to means, methods and cassettes for the automated synthesis of the radiotracer 6-L-[18F]fluoro-3,4- dihydroxyphenylalanine (6-L-[18F]FDOPA). Provided is a method for the one-pot synthesis of 6-L-[18F]FDOPA comprising contacting a BOC- protected stannyl precursor of the formula I with [18F] Tetraethylammonium fluoride ([18F]Et4NF) in the presence of the Cu-catalyst Cu(Impy)4(OTf)2.

Original language	English
Patent number	WO2024058665
Priority date	15/09/2022
Filing date	14/09/2023
Publication status	Published - 21-Mar-2024

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title = "One-pot synthesis of 6-l-[18f] fluoro-3,4-dihydroxyphenylalanine (6-l-[18f] fdopa).",

abstract = "The invention relates to the field of medicinal chemistry and radiopharmaceuticals, in particular to means, methods and cassettes for the automated synthesis of the radiotracer 6-L-[18F]fluoro-3,4- dihydroxyphenylalanine (6-L-[18F]FDOPA). Provided is a method for the one-pot synthesis of 6-L-[18F]FDOPA comprising contacting a BOC- protected stannyl precursor of the formula I with [18F] Tetraethylammonium fluoride ([18F]Et4NF) in the presence of the Cu-catalyst Cu(Impy)4(OTf)2.",

author = "Geert Luurtsema and Chantal Kwizera and Blok, {Simon Niels} and {Farinha Antunes}, Ines and Elsinga, {Philippus Hein} and {de Vries}, Erik",

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month = mar,

day = "21",

language = "English",

type = "Patent",

note = "WO2024058665",

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TY - PAT

T1 - One-pot synthesis of 6-l-[18f] fluoro-3,4-dihydroxyphenylalanine (6-l-[18f] fdopa).

AU - Luurtsema, Geert

AU - Kwizera, Chantal

AU - Blok, Simon Niels

AU - Farinha Antunes, Ines

AU - Elsinga, Philippus Hein

AU - de Vries, Erik

PY - 2024/3/21

Y1 - 2024/3/21

N2 - The invention relates to the field of medicinal chemistry and radiopharmaceuticals, in particular to means, methods and cassettes for the automated synthesis of the radiotracer 6-L-[18F]fluoro-3,4- dihydroxyphenylalanine (6-L-[18F]FDOPA). Provided is a method for the one-pot synthesis of 6-L-[18F]FDOPA comprising contacting a BOC- protected stannyl precursor of the formula I with [18F] Tetraethylammonium fluoride ([18F]Et4NF) in the presence of the Cu-catalyst Cu(Impy)4(OTf)2.

AB - The invention relates to the field of medicinal chemistry and radiopharmaceuticals, in particular to means, methods and cassettes for the automated synthesis of the radiotracer 6-L-[18F]fluoro-3,4- dihydroxyphenylalanine (6-L-[18F]FDOPA). Provided is a method for the one-pot synthesis of 6-L-[18F]FDOPA comprising contacting a BOC- protected stannyl precursor of the formula I with [18F] Tetraethylammonium fluoride ([18F]Et4NF) in the presence of the Cu-catalyst Cu(Impy)4(OTf)2.

M3 - Patent

M1 - WO2024058665

Y2 - 2023/09/14

ER -

One-pot synthesis of 6-l-[18f] fluoro-3,4-dihydroxyphenylalanine (6-l-[18f] fdopa).

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