One-year severity of depressive symptoms: Results from the NESDA study

F. Lamers, A.T. Beekman, P. de Jonge, J.H. Smit, W.A. Nolen, B.W. Penninx

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Abstract

The aim of this study was to simultaneously examine a wide range of risk factors and clinical characteristics in their predictive value for the one-year severity of depressive symptoms. Data from 789 participants in the Netherlands Study of Depression and Anxiety (NESDA), a large psychiatric cohort study, with a major depressive disorder (MDD) at baseline were used. Depression severity at one-year follow-up was studied using linear and multinomial logistic regression models. Results of the analyses showed that high neuroticism, no partner and older age were found predictive of a poorer outcome independent of baseline clinical characteristics. Further, comorbid anxiety disorder, first episode, having a moderate subtype (vs. melancholic), and higher baseline depression severity predicted poorer outcome. To conclude, both risk factors and clinical characteristics independently predicted one-year severity of depressive symptoms. This implies that the prediction of prognosis and identification of persons at risk of a poor outcome should not only be based on clinical characteristics, but on risk factors as well
Original languageEnglish
Pages (from-to)226-231
Number of pages6
JournalPsychiatry Research
Volume190
Issue number2-3
DOIs
Publication statusPublished - 30-Dec-2011

Keywords

  • Psychiatric epidemiology
  • Longitudinal cohort
  • Depressive disorder
  • Risk factors
  • Clinical characteristics
  • MENTAL-HEALTH SURVEY
  • STAR-ASTERISK-D
  • STRESSFUL LIFE EVENTS
  • PROSPECTIVE FOLLOW-UP
  • REPORT QIDS-SR
  • MAJOR DEPRESSION
  • PSYCHOMETRIC EVALUATION
  • DEVELOPMENTAL MODEL
  • MULTIPLE IMPUTATION
  • GENERAL-POPULATION

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