Opportunities for interfacing organometallic catalysts with cellular metabolism

Rudy Rubini, Clemens Mayer*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


A concerted effort of synthetic chemistry and synthetic biology promises to expand biological function without the need for extensive genetic manipulation. In such scenarios, man-made catalysts perform new-to-nature transformations on molecules, which are either provided or further diversified by biocatalysts in designer microbes. Here, we highlight the potential of interfacing man-made catalysts with cellular metabolism by discussing the importance of non-enzymatic, metal-catalyzed transformations in nature, means to identify biocompatible transition-metal complexes and their successful integration with cellular metabolism. Lastly, we provide a critical analysis of future prospects and remaining challenges for the applications of biocompatible catalysts in synthetic chemistry, biotechnology, and biomedicine.
Original languageEnglish
Title of host publicationApplications IV
Subtitle of host publicationBio-organometallics, Metallo-Therapy, Metallo-Diagnostics, Medicine and Environmental Chemistry
EditorsLena J. Daumann
Place of PublicationElsevier
Number of pages25
ISBN (Electronic)9780323913508
Publication statusPublished - 5-Aug-2022

Publication series

NameComprehensive Organometallic Chemistry IV

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