Optimization of 11C-choline positron emission tomography protocol for localization of parathyroid adenomas in patients with primary hyperparathyroidism

M.E. Noltes, S. Kruijf, W. Noordzij, E. Telenga, D. Vállez García, M. Trofmiuk-Müldner, M. Opalínska, A. Hubalewska-Dydejczyk, G. Luurtsema, R.A.J.O. Dierckx, M. El Moumni, R. Boellaard, A.H. Brouwers

Research output: Contribution to journalMeeting AbstractAcademic


Purpose: To evaluate the optimal tracer uptake time, the minimally amount of radioactivity and the inter-observer agree-ment for 11C-choline positron emission tomography/computed tomography (PET/CT) in patients with primary hyperparathy-roidism (pHPT). Subjects & methods: Twenty-one patients with clinically suspected pHPT were retrospectively studied after injection of mean 6.3 ± 1.2 MBq/kg. PET list mode data of the first nine patients, scanned for up to max 60 min, were reconstructed in 10 min frames mimicking varying 11C-choline uptake times from 10 to 60 min postinjection (p.i.) to assess optimal tracer uptake time. Parathyroid adenoma (PTA) to background contrast ratios were calculated, using standardized uptake values (SUVs), and compared. The first time frame in which there were no significant differences compared to later time frames, was considered the optimal uptake time. Also, data was reconstructed with varying durations (1, 2.5 and 5 min) at 20-30 min p.i. (established optimal uptake time), mimicking less administered radioactivity. To establish the minimal radioactivity administered, the variability of SUVs for PTA and thyroid tissue, normalized to 10 min time frame level of the established optimal uptake time (since the individual measurements of SUV per patient varied considerably), was analysed. Furthermore, four observers were asked to analyse the 11C-choline uptake for PET/CT scans in four randomized rounds for all 21 patients, with increasing scan duration per round. P-values of
Original languageEnglish
Pages (from-to)89
Number of pages1
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Publication statusPublished - 1-Oct-2018
Event31st Annual Congress of the European Association of Nuclear Medicine (EANM) - Dusseldorf, Germany
Duration: 13-Oct-201817-Oct-2018
Conference number: 31


  • choline
  • tracer
  • adult
  • choline uptake
  • clinical article
  • conference abstract
  • controlled study
  • female
  • human
  • human tissue
  • injection
  • male
  • mean standardized uptake value
  • parathyroid adenoma
  • positron emission tomography-computed tomography
  • primary hyperparathyroidism
  • radioactivity
  • randomized controlled trial
  • retrospective study
  • statistical significance
  • thyroid gland tissue

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