Oral antimicrobial activity weakened in children with electronic waste lead exposure

Shaocheng Zhang, Xia Huo, Minghui Li, Ruikun Hou, Xiaowei Cong, Xijin Xu*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    Environmental lead (Pb) exposure can induce dysbacteriosis, impair oral health, and is associated with the development of dental caries. However, the mechanism is unclear. The aim of this study was to explore the effects of Pb toxicity on oral antimicrobial activity in children in an e-waste area. Results showed higher blood Pb levels in e-waste-exposed group children, accompanied by decreased saliva SAG (salivary agglutinin) concentrations, increased peripheral WBC (white blood cell) counts and monocyte counts, and elevated peripheral monocyte percentage. LnPb (natural logarithmic transformation of blood Pb level) was negatively correlated with saliva SAG concentration, while positively correlated with peripheral monocyte percentage. Saliva SAG concentration played a complete mediating role in the correlation of LnPb to peripheral monocyte percentage. To our knowledge, this is the first study on the relationship of environmental Pb exposure and oral antimicrobial activity in children, showing that environmental Pb exposure may weaken oral antimicrobial activity through reducing saliva SAG concentration, which may raise the risk of oral dysbacteriosis and ultimately pathogen infection.

    Original languageEnglish
    Pages (from-to)14763-14770
    Number of pages8
    JournalEnvironmental Science and Pollution Research
    Volume27
    Issue number13
    DOIs
    Publication statusPublished - May-2020

    Keywords

    • Oral antimicrobial activity
    • Children
    • Lead exposure
    • Peripheral monocyte percentage
    • Saliva salivary agglutinin
    • Electronic waste
    • SALIVARY AGGLUTININ
    • DENTAL-CARIES
    • PRESCHOOL-CHILDREN
    • BLOOD MORPHOLOGY
    • RECYCLING TOWN
    • GUT MICROBIOTA
    • HEAVY-METALS
    • INNATE
    • RISK
    • ASSOCIATION

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