TY - PAT
T1 - Oral dosage forms of a therapeutically active acid-labile salt and methods and uses related thereto.
AU - Frijlink, Henderik Willem
AU - Eissens, Anko Cornelus
AU - van Goor, Harm
AU - Mulder, Douwe Johannes
AU - Joles, Jacob Alexander
PY - 2023/7/27
Y1 - 2023/7/27
N2 - The invention relates to the field of oral drug delivery and more in particular, to oral dosage forms for delivery of a high dose of a therapeutically active acid-labile salt, such as sodium thiosulfate (STS). Provided is a pharmaceutical oral dosage form for controlled delivery of an acid-labile salt, the dosage form comprising a core comprising the acid-labile salt in a polymer matrix comprising a combination of (i) a pH- sensitive hydrophilic methacrylic acid— methyl methacrylate copolymer and (ii) a carbomer, wherein the acid-labile salt makes up at least 50wt% of the core; and wherein the outer surface of the core is provided with an enteric coating layer.
AB - The invention relates to the field of oral drug delivery and more in particular, to oral dosage forms for delivery of a high dose of a therapeutically active acid-labile salt, such as sodium thiosulfate (STS). Provided is a pharmaceutical oral dosage form for controlled delivery of an acid-labile salt, the dosage form comprising a core comprising the acid-labile salt in a polymer matrix comprising a combination of (i) a pH- sensitive hydrophilic methacrylic acid— methyl methacrylate copolymer and (ii) a carbomer, wherein the acid-labile salt makes up at least 50wt% of the core; and wherein the outer surface of the core is provided with an enteric coating layer.
M3 - Patent
M1 - WO2023140729
Y2 - 2023/01/18
ER -