Oral dosage forms of a therapeutically active acid-labile salt and methods and uses related thereto.

Henderik Willem Frijlink (Inventor), Anko Cornelus Eissens (Inventor), Harm van Goor (Inventor), Douwe Johannes Mulder (Inventor), Jacob Alexander Joles (Inventor)

Research output: Patent

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Abstract

The invention relates to the field of oral drug delivery and more in particular, to oral dosage forms for delivery of a high dose of a therapeutically active acid-labile salt, such as sodium thiosulfate (STS). Provided is a pharmaceutical oral dosage form for controlled delivery of an acid-labile salt, the dosage form comprising a core comprising the acid-labile salt in a polymer matrix comprising a combination of (i) a pH- sensitive hydrophilic methacrylic acid— methyl methacrylate copolymer and (ii) a carbomer, wherein the acid-labile salt makes up at least 50wt% of the core; and wherein the outer surface of the core is provided with an enteric coating layer.
Original languageEnglish
Patent numberWO2023140729
Priority date18/01/2022
Filing date18/01/2023
Publication statusPublished - 27-Jul-2023

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