Organocatalyst based cross-catalytic system

Marieke J. Veenstra; Syuzanna R. Harutyunyan

doi:10.1039/d2cc05610k

Organocatalyst based cross-catalytic system

Marieke J. Veenstra
, Syuzanna R. Harutyunyan^*

^*Corresponding author for this work

Homogeneous Catalysis

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Abstract

We present our design of a cross-catalytic system based on organocatalysis. The system features two organic reactions, namely a deprotection reaction of Fmoc protected proline and a Mannich reaction between acetone and dihydroisoquinoline. The products of these two reactions, proline and a tetrahydroisoquinoline, respectively, are capable of reciprocal reaction rate enhancement. Detailed kinetic studies of the system and seeding experiments support the cross-catalytic relationship in the reaction network.

Original language	English
Pages (from-to)	13895-13898
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	100
DOIs	https://doi.org/10.1039/d2cc05610k
Publication status	Published - 18-Nov-2022

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title = "Organocatalyst based cross-catalytic system",

abstract = "We present our design of a cross-catalytic system based on organocatalysis. The system features two organic reactions, namely a deprotection reaction of Fmoc protected proline and a Mannich reaction between acetone and dihydroisoquinoline. The products of these two reactions, proline and a tetrahydroisoquinoline, respectively, are capable of reciprocal reaction rate enhancement. Detailed kinetic studies of the system and seeding experiments support the cross-catalytic relationship in the reaction network.",

author = "Veenstra, \{Marieke J.\} and Harutyunyan, \{Syuzanna R.\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",

year = "2022",

month = nov,

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doi = "10.1039/d2cc05610k",

language = "English",

volume = "58",

pages = "13895--13898",

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AU - Veenstra, Marieke J.

AU - Harutyunyan, Syuzanna R.

PY - 2022/11/18

Y1 - 2022/11/18

N2 - We present our design of a cross-catalytic system based on organocatalysis. The system features two organic reactions, namely a deprotection reaction of Fmoc protected proline and a Mannich reaction between acetone and dihydroisoquinoline. The products of these two reactions, proline and a tetrahydroisoquinoline, respectively, are capable of reciprocal reaction rate enhancement. Detailed kinetic studies of the system and seeding experiments support the cross-catalytic relationship in the reaction network.

AB - We present our design of a cross-catalytic system based on organocatalysis. The system features two organic reactions, namely a deprotection reaction of Fmoc protected proline and a Mannich reaction between acetone and dihydroisoquinoline. The products of these two reactions, proline and a tetrahydroisoquinoline, respectively, are capable of reciprocal reaction rate enhancement. Detailed kinetic studies of the system and seeding experiments support the cross-catalytic relationship in the reaction network.

UR - https://www.scopus.com/pages/publications/85143915840

U2 - 10.1039/d2cc05610k

DO - 10.1039/d2cc05610k

M3 - Article

C2 - 36448644

AN - SCOPUS:85143915840

SN - 1359-7345

VL - 58

SP - 13895

EP - 13898

JO - Chemical Communications

JF - Chemical Communications

IS - 100

ER -

Organocatalyst based cross-catalytic system

Abstract

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