Organophosphorus pesticide poisoning: cases and developments

H. Aardema; J. J. M. Ligtenberg; O. M. Peters-Polman; J. E. Tulleken; J. G. Zijlstra; John H. J. M. Meertens

Organophosphorus pesticide poisoning: cases and developments

H. Aardema^*, J. J. M. Ligtenberg, O. M. Peters-Polman, J. E. Tulleken, J. G. Zijlstra, John H. J. M. Meertens

^*Corresponding author for this work

Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)

Research output: Contribution to journal › Review article › peer-review

78 Citations (Scopus)

Abstract

Self-poisoning with organophosphate pesticides is a major health problem world-wide. Through the inhibition of acetylcholinesterase, organophosphorus poisoning is characterised by the clinical picture of acute cholinergic crisis. Other manifestations are the intermediate neurotoxic syndrome and delayed polyneuropathy.

In the Western world, the occurrence of organophosphorus poisoning is less prevalent due to the declining availability of organophosphate pesticides, which could render the recognition of this particular type of intoxication and its specific treatment more difficult.

In this article we discuss some recent developments and treatment dilemmas, illustrated by cases from our clinic, followed by a review of the current recommendations in the treatment of organophosphate poisoning.

Original language	English
Pages (from-to)	149-153
Number of pages	5
Journal	Netherlands Journal of Medicine
Volume	66
Issue number	4
Publication status	Published - Apr-2008

Keywords

diagnosis
intoxication
oximes
parathion
treatment
CHOLINESTERASE INHIBITION
SECONDARY CONTAMINATION
DEVELOPING-WORLD
OXIME THERAPY
PRALIDOXIME
MANAGEMENT

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Cite this

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title = "Organophosphorus pesticide poisoning: cases and developments",

abstract = "Self-poisoning with organophosphate pesticides is a major health problem world-wide. Through the inhibition of acetylcholinesterase, organophosphorus poisoning is characterised by the clinical picture of acute cholinergic crisis. Other manifestations are the intermediate neurotoxic syndrome and delayed polyneuropathy.In the Western world, the occurrence of organophosphorus poisoning is less prevalent due to the declining availability of organophosphate pesticides, which could render the recognition of this particular type of intoxication and its specific treatment more difficult.In this article we discuss some recent developments and treatment dilemmas, illustrated by cases from our clinic, followed by a review of the current recommendations in the treatment of organophosphate poisoning.",

keywords = "diagnosis, intoxication, oximes, parathion, treatment, CHOLINESTERASE INHIBITION, SECONDARY CONTAMINATION, DEVELOPING-WORLD, OXIME THERAPY, PRALIDOXIME, MANAGEMENT",

author = "H. Aardema and Ligtenberg, {J. J. M.} and Peters-Polman, {O. M.} and Tulleken, {J. E.} and Zijlstra, {J. G.} and Meertens, {John H. J. M.}",

year = "2008",

month = apr,

language = "English",

volume = "66",

pages = "149--153",

journal = "Netherlands Journal of Medicine",

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TY - JOUR

T1 - Organophosphorus pesticide poisoning

T2 - cases and developments

AU - Aardema, H.

AU - Ligtenberg, J. J. M.

AU - Peters-Polman, O. M.

AU - Tulleken, J. E.

AU - Zijlstra, J. G.

AU - Meertens, John H. J. M.

PY - 2008/4

Y1 - 2008/4

N2 - Self-poisoning with organophosphate pesticides is a major health problem world-wide. Through the inhibition of acetylcholinesterase, organophosphorus poisoning is characterised by the clinical picture of acute cholinergic crisis. Other manifestations are the intermediate neurotoxic syndrome and delayed polyneuropathy.In the Western world, the occurrence of organophosphorus poisoning is less prevalent due to the declining availability of organophosphate pesticides, which could render the recognition of this particular type of intoxication and its specific treatment more difficult.In this article we discuss some recent developments and treatment dilemmas, illustrated by cases from our clinic, followed by a review of the current recommendations in the treatment of organophosphate poisoning.

AB - Self-poisoning with organophosphate pesticides is a major health problem world-wide. Through the inhibition of acetylcholinesterase, organophosphorus poisoning is characterised by the clinical picture of acute cholinergic crisis. Other manifestations are the intermediate neurotoxic syndrome and delayed polyneuropathy.In the Western world, the occurrence of organophosphorus poisoning is less prevalent due to the declining availability of organophosphate pesticides, which could render the recognition of this particular type of intoxication and its specific treatment more difficult.In this article we discuss some recent developments and treatment dilemmas, illustrated by cases from our clinic, followed by a review of the current recommendations in the treatment of organophosphate poisoning.

KW - diagnosis

KW - intoxication

KW - oximes

KW - parathion

KW - treatment

KW - CHOLINESTERASE INHIBITION

KW - SECONDARY CONTAMINATION

KW - DEVELOPING-WORLD

KW - OXIME THERAPY

KW - PRALIDOXIME

KW - MANAGEMENT

M3 - Review article

SN - 0300-2977

VL - 66

SP - 149

EP - 153

JO - Netherlands Journal of Medicine

JF - Netherlands Journal of Medicine

IS - 4

ER -