TY - JOUR
T1 - Ornithine decarboxylase activity in prostate and tumor
T2 - A feasibility study for PET with l-[1-14C]- and l-[5-14C]ornithine
AU - Elsinga, Ph. H.
AU - Daemen, B. J. G.
AU - Ishiwata, K.
AU - Vaalburg, W.
PY - 1990
Y1 - 1990
N2 - The aim of this study is to investigate the possibility of measuring ornithine decarboxylase (ODC) activity in tissues such as prostate and tumor, by PET. The ODC activity in vitro and the distribution of l-[1-14C]- and l-[5-14C]ornithine were studied in prostate, tumor, liver and kidney. For the animal models, rats bearing Walker 256 carcinosarcoma, were used. Our results indicate that the ODC activity in prostate is correlated with the difference in uptake between l-[1-14C]- and l-[5-14C]ornithine. Measurement of ODC activity in tumor by PET demands a tumor with an ODC activity comparable to that of prostate. Such a tumor will show a sufficient difference in uptake, which can be detected by PET.
AB - The aim of this study is to investigate the possibility of measuring ornithine decarboxylase (ODC) activity in tissues such as prostate and tumor, by PET. The ODC activity in vitro and the distribution of l-[1-14C]- and l-[5-14C]ornithine were studied in prostate, tumor, liver and kidney. For the animal models, rats bearing Walker 256 carcinosarcoma, were used. Our results indicate that the ODC activity in prostate is correlated with the difference in uptake between l-[1-14C]- and l-[5-14C]ornithine. Measurement of ODC activity in tumor by PET demands a tumor with an ODC activity comparable to that of prostate. Such a tumor will show a sufficient difference in uptake, which can be detected by PET.
U2 - 10.1016/0883-2897(90)90135-N
DO - 10.1016/0883-2897(90)90135-N
M3 - Article
SN - 0883-2897
VL - 17
SP - 597
EP - 600
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
IS - 6
ER -