Orthogonal Control of Antibacterial Activity with Light

Willem A. Velema, Jan Pieter van der Berg, Wiktor Szymanski, Arnold J. M. Driessen, Ben L. Feringa*

*Corresponding author for this work

Research output: Contribution to journalLetterAcademicpeer-review

54 Citations (Scopus)

Abstract

Selection of a single bacterial strain out of a mixture of microorganisms is of crucial importance in healthcare and microbiology research. Novel approaches that can externally control bacterial selection are a valuable addition to the microbiology toolbox. In this proof-of-concept, two complementary antibiotics are protected with photocleavable groups that can be orthogonally addressed with different wavelengths of light. This allows for the light-triggered selection of a single bacterial strain out of a mixture of multiple strains, by choosing the right wavelength. Further improvement toward additional orthogonally addressable antibiotics might ultimately lead to a novel methodology for bacterial selection in complex populations.

Original languageEnglish
Pages (from-to)1969-1974
Number of pages6
JournalACS chemical biology
Volume9
Issue number9
DOIs
Publication statusPublished - Sep-2014

Keywords

  • OPTICAL CONTROL
  • AZOBENZENE
  • INHIBITORS
  • PROTEIN
  • SWITCH
  • TOOLS
  • COLOR
  • GABA

Cite this