Oscillatory activity and cortical coherence of the nucleus basalis of Meynert in Parkinson's disease dementia

Muhammad Nazmuddin, D. L. Marinus Oterdoom, J. Marc C. van Dijk, Jonathan C. van Zijl, Anne K. Kampman, Gea Drost, Teus van Laar, Martijn Beudel*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Background: Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) is a new potential treatment for Parkinson's Disease dementia (PDD) and other types of dementia. To get a better understanding of this structure, its local neurophysiological properties and cortical connectivity patterns were studied.

Methods: We simultaneously recorded DBS local field potentials (LFPs) and electroencephalography (EEG) in two patients with PDD. Both patients had DBS electrodes in the internal globus pallidus (GPi) with one or more distal contacts close to or inside the NBM. Measurements were obtained during routine battery replacement. The distance of DBS contacts to the NBM were calculated using CT-MRI fusion.

Results: Delta (1-4 Hz) oscillations were more prominently present in the NBM region than in its vicinity, whereas temporal coherence in the theta (4-8 Hz) range was less outspoken.

Conclusion: These neurophysiological characteristics, if also proven in larger cohorts, might help to map the NBM more precisely during electrode implantation. (C) 2018 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalParkinsonism & Related Disorders
Volume52
Early online date28-Mar-2018
DOIs
Publication statusPublished - Jul-2018

Keywords

  • Nucleus basalis of Meynert
  • Parkinson's disease dementia
  • STIMULATION
  • ALZHEIMERS

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