Outcome of late-life depression after 3 years of sequential treatment

R. M. Kok*, W. A. Nolen, T. J. Heeren

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Abstract

To study the outcome of a sequential treatment protocol in elderly, severely depressed in-patients.

All 81 patients from a 12-week double-blind randomized controlled trial (RCT) comparing venlafaxine with nortriptyline were asked to participate in a 3 year follow-up study. Thirty-two patients who did not achieve remission during the RCT, entered an open sequential treatment protocol and were treated with augmentation with lithium, switch to a monoamine oxidase inhibitor or ECT.

Seventy-eight of the 81 patients (96.3%) achieved a response [>= 50% reduction in Montgomery angstrom sberg Depression Rating Scale score) and 68 patients (84%) a complete remission (final MADRS score

Our study demonstrates the importance of persisting with antidepressant treatment in elderly patients who do not respond to the first or second treatment.

Original languageEnglish
Pages (from-to)274-281
Number of pages8
JournalActa Psychiatrica Scandinavica
Volume119
Issue number4
DOIs
Publication statusPublished - Apr-2009

Keywords

  • depressive disorder
  • aged
  • in-patients
  • antidepressive agents
  • ASTERISK-D REPORT
  • PRIMARY-CARE PATIENTS
  • GERIATRIC DEPRESSION
  • MAJOR DEPRESSION
  • OLDER-ADULTS
  • AUGMENTATION
  • REMISSION
  • PROGNOSIS
  • ALGORITHM
  • RECOVERY

Cite this