Ovarian hyperstimulation and the in vitro fertilization procedure do not influence early neuromotor development; a history of subfertility does

Karin J. Middelburg*, Maaike L. Haadsma, Maas Jan Heineman, Arend F. Bos, Mijna Hadders-Algra

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Abstract

Objective: To evaluate specific effects of ovarian hyperstimulation, the in vitro procedure, and a history of subfertility on neuromotor development at 3 months of age.

Design: Prospective, cohort study.

Setting: University Medical Center Groningen, The Netherlands.

Patient(s): Singletons conceived after controlled ovarian hyperstimulation-IVF/intracytoplasmic sperm injection (COH-IVF: n = 68) or modified natural cycle-IVF/intracytoplasmic sperm injection (MNC-IVF; n = 57), and naturally conceived singletons of subfertile couples (NC; n = 90). Data from a reference population were available (n = 450).

Intervention(S): None.

Main Outcome Measure(s): Quality of general movements (GMs), classified as normal-optimal, normal-suboptimal, mildly abnormal, or definitely abnormal. Definitely abnormal GMs indicate brain dysfunction, mildly abnormal GMs normal but non-optimal brain function.

Result(s): Mildly abnormal and definitely abnormal GMs were observed equally frequently in COH-IVF, MNC-IVF, and NC singletons. The three subfertile groups showed a reduction in GM quality, in particular more mildly abnormal GMs, in comparison with the reference population.

Conclusion(s): Singletons born after IVF (with or without ovarian hyperstimulation) are not at increased risk for abnormal GMs compared with naturally conceived peers of subfertile parents. Mildly abnormal GMs occur more often in infants of subfertile parents than in the general population, suggesting that factors associated with subfertility rather than those related to IVF procedures may be associated with less-optimal early neurodevelopmental outcome. These results need confirmation through replication and follow-up at older ages. (Fertil Steril(R) 2010;93:544-53. (C)2010 by American Society for Reproductive Medicine.)

Original languageEnglish
Pages (from-to)544-553
Number of pages10
JournalFertility and sterility
Volume93
Issue number2
DOIs
Publication statusPublished - 15-Jan-2010
Event24th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE) - , Spain
Duration: 6-Jul-20089-Jul-2008

Keywords

  • Assisted reproductive technology
  • children
  • child development
  • general movements
  • infant
  • IVF
  • ASSISTED REPRODUCTIVE TECHNOLOGY
  • INTRACYTOPLASMIC SPERM INJECTION
  • MINOR NEUROLOGICAL DYSFUNCTION
  • CUMULATIVE PREGNANCY RATES
  • HEALTHY TERM INFANTS
  • NATURAL CYCLE IVF
  • LOW-BIRTH-WEIGHT
  • CHILDREN BORN
  • GENERAL MOVEMENTS
  • BEHAVIORAL OUTCOMES

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