Overexpression of mineralocorticoid receptors does not affect memory and anxiety-like behavior in female mice

Sofia Kanatsou*, Laura E. Kuil, Marit Arp, Melly S. Oitzl, Anjanette P. Harris, Jonathan R. Seckl, Harm J. Krugers, Marian Joels

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Mineralocorticoid receptors (MRs) have been implicated in behavioral adaptation and learning and memory. Since at least in humans-MR function seems to be sex-dependent, we examined the behavioral relevance of MR in female mice exhibiting transgenic MR overexpression in the forebrain. Transgenic MR overexpression did not affect contextual fear memory or cued fear learning and memory. Moreover, MR overexpressing and control mice discriminated equally well between fear responses in a combined cue and context fear conditioning paradigm. Also context memory in an object recognition task was unaffected in MR overexpressing mice. We conclude that MR overexpression in female animals does not affect fear conditioned responses and object recognition memory.

Original languageEnglish
Article number182
Number of pages9
JournalFrontiers in Behavioral Neuroscience
Volume9
DOIs
Publication statusPublished - 14-Jul-2015
Externally publishedYes

Keywords

  • fear
  • memory
  • mineralocorticoid receptor
  • hippocampus
  • sex
  • anxiety
  • STRESS HORMONE CORTICOSTERONE
  • GLUCOCORTICOID-RECEPTORS
  • CONTEXT RECOGNITION
  • OBJECT RECOGNITION
  • BRAIN
  • RATS
  • SYSTEMS
  • SEX
  • TRANSMISSION
  • PERFORMANCE

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