Oxygen-releasing poly(trimethylene carbonate) microspheres for tissue engineering applications

Hilde Steg, Arina T. Buizer, Willem Woudstra, Albert G. Veldhuizen, Sjoerd K. Bulstra, Dirk W. Grijpma, Roel Kuijer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

The introduction of tissue engineering therapies for the repair of bone defects has been limited by poor survival of implanted cells. Because of the absence of a vascular network, the cells in a cell-scaffold construct are not adequately supplied with oxygen and nutrients. Thus far, all but one strategies to solve this problem have failed. Fortunately, oxygen-delivering biomaterials have shown promising results. In this study, composite microspheres comprising a poly(trimethylene carbonate) matrix and calcium peroxide particles (PTMC/CaO2) were prepared and assessed for their oxygen-delivering capacity and potential cytotoxicity. PTMC/CaO2 composite microspheres were shown to release oxygen for several weeks. Oxygen release appeared to be dependent on the presence of cholesterol esterase in the medium. The microspheres were not cytotoxic and promoted mesenchymal stromal cell proliferation under hypoxic conditions in vitro.

Original languageEnglish
Pages (from-to)1252-1257
Number of pages6
JournalPolymers for Advanced Technologies
Volume28
Issue number10
Early online date20-Sep-2016
DOIs
Publication statusPublished - Oct-2017

Keywords

  • poly(trimethylene carbonate)
  • microspheres
  • slow release
  • oxygen
  • hMSC

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