P-NGAL Day 1 predicts early but not one year graft function following deceased donor kidney transplantation - The CONTEXT study

Marie B. Nielsen; Nicoline V. Krogstrup; Gertrude J. Nieuwenhuijs-Moeke; Mihai Oltean; Frank J. M. F. Dor; Bente Jespersen; Henrik Birn

doi:10.1371/journal.pone.0212676

P-NGAL Day 1 predicts early but not one year graft function following deceased donor kidney transplantation - The CONTEXT study

Marie B. Nielsen^*, Nicoline V. Krogstrup, Gertrude J. Nieuwenhuijs-Moeke, Mihai Oltean, Frank J. M. F. Dor, Bente Jespersen, Henrik Birn

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

151 Downloads (Pure)

Abstract

Background

Early markers to predict delayed kidney graft function (DGF) may support clinical management. We studied the ability of four biomarkers (neutrophil gelatinase associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), cystatin C, and YKL-40) to predict DGF after deceased donor transplantation, and their association with early graft function and GFR at three and twelve months.

Methods

225 deceased donor kidney transplant recipients were included. Biomarkers were measured using automated assays or ELISA. We calculated their ability to predict the need for dialysis post-transplant and correlated with the estimated time to a 50% reduction in plasma creatinine (tCr50), measured glomerular filtration rate (mGFR) and estimated GFR (eGFR).

Results

All biomarkers measured at Day 1, except urinary L-FABP, significantly correlated with tCr50 and mGFR at Day 5. Plasma NGAL at Day 1 and a timed urine output predicted DGF (AUC = 0.91 and AUC 0.98). Nil or only weak correlations were identified between early bio-arker levels and mGFR or eGFR at three or twelve months.

Conclusion

High plasma NGAL at Day 1 predicts DGF and is associated with initial graft function, but may not prove better than P-creatinine or a timed urine output. Early biomarker levels do not correlate with one-year graft function.

Trial registration

ClinicalTrials.gov NCT01395719

Original language	English
Article number	0212676
Number of pages	14
Journal	PLoS ONE
Volume	14
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0212676
Publication status	Published - 28-Feb-2019

Keywords

GELATINASE-ASSOCIATED LIPOCALIN
ACID-BINDING PROTEIN
GLOMERULAR-FILTRATION-RATE
RENAL-TRANSPLANTATION
CARDIAC DEATH
CREATININE
BIOMARKERS
INJURY
RECIPIENTS
OUTCOMES

Access to Document

10.1371/journal.pone.0212676Licence: CC BY

P-NGAL Day 1 predicts early but not one year graft function following deceased donor kidney transplantation – The CONTEXT studyFinal publisher's version, 1.12 MBLicence: CC BY

Handle.net

Persistent link

Cite this

@article{b00dfb900c7f4755bb3fcc6684b31760,

title = "P-NGAL Day 1 predicts early but not one year graft function following deceased donor kidney transplantation - The CONTEXT study",

abstract = "BackgroundEarly markers to predict delayed kidney graft function (DGF) may support clinical management. We studied the ability of four biomarkers (neutrophil gelatinase associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), cystatin C, and YKL-40) to predict DGF after deceased donor transplantation, and their association with early graft function and GFR at three and twelve months.Methods225 deceased donor kidney transplant recipients were included. Biomarkers were measured using automated assays or ELISA. We calculated their ability to predict the need for dialysis post-transplant and correlated with the estimated time to a 50% reduction in plasma creatinine (tCr50), measured glomerular filtration rate (mGFR) and estimated GFR (eGFR).ResultsAll biomarkers measured at Day 1, except urinary L-FABP, significantly correlated with tCr50 and mGFR at Day 5. Plasma NGAL at Day 1 and a timed urine output predicted DGF (AUC = 0.91 and AUC 0.98). Nil or only weak correlations were identified between early bio-arker levels and mGFR or eGFR at three or twelve months.ConclusionHigh plasma NGAL at Day 1 predicts DGF and is associated with initial graft function, but may not prove better than P-creatinine or a timed urine output. Early biomarker levels do not correlate with one-year graft function.Trial registrationClinicalTrials.gov NCT01395719",

keywords = "GELATINASE-ASSOCIATED LIPOCALIN, ACID-BINDING PROTEIN, GLOMERULAR-FILTRATION-RATE, RENAL-TRANSPLANTATION, CARDIAC DEATH, CREATININE, BIOMARKERS, INJURY, RECIPIENTS, OUTCOMES",

author = "Nielsen, {Marie B.} and Krogstrup, {Nicoline V.} and Nieuwenhuijs-Moeke, {Gertrude J.} and Mihai Oltean and Dor, {Frank J. M. F.} and Bente Jespersen and Henrik Birn",

year = "2019",

month = feb,

day = "28",

doi = "10.1371/journal.pone.0212676",

language = "English",

volume = "14",

journal = "PLOS-One",

issn = "1932-6203",

publisher = "PUBLIC LIBRARY SCIENCE",

number = "2",

}

TY - JOUR

T1 - P-NGAL Day 1 predicts early but not one year graft function following deceased donor kidney transplantation - The CONTEXT study

AU - Nielsen, Marie B.

AU - Krogstrup, Nicoline V.

AU - Nieuwenhuijs-Moeke, Gertrude J.

AU - Oltean, Mihai

AU - Dor, Frank J. M. F.

AU - Jespersen, Bente

AU - Birn, Henrik

PY - 2019/2/28

Y1 - 2019/2/28

N2 - BackgroundEarly markers to predict delayed kidney graft function (DGF) may support clinical management. We studied the ability of four biomarkers (neutrophil gelatinase associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), cystatin C, and YKL-40) to predict DGF after deceased donor transplantation, and their association with early graft function and GFR at three and twelve months.Methods225 deceased donor kidney transplant recipients were included. Biomarkers were measured using automated assays or ELISA. We calculated their ability to predict the need for dialysis post-transplant and correlated with the estimated time to a 50% reduction in plasma creatinine (tCr50), measured glomerular filtration rate (mGFR) and estimated GFR (eGFR).ResultsAll biomarkers measured at Day 1, except urinary L-FABP, significantly correlated with tCr50 and mGFR at Day 5. Plasma NGAL at Day 1 and a timed urine output predicted DGF (AUC = 0.91 and AUC 0.98). Nil or only weak correlations were identified between early bio-arker levels and mGFR or eGFR at three or twelve months.ConclusionHigh plasma NGAL at Day 1 predicts DGF and is associated with initial graft function, but may not prove better than P-creatinine or a timed urine output. Early biomarker levels do not correlate with one-year graft function.Trial registrationClinicalTrials.gov NCT01395719

AB - BackgroundEarly markers to predict delayed kidney graft function (DGF) may support clinical management. We studied the ability of four biomarkers (neutrophil gelatinase associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), cystatin C, and YKL-40) to predict DGF after deceased donor transplantation, and their association with early graft function and GFR at three and twelve months.Methods225 deceased donor kidney transplant recipients were included. Biomarkers were measured using automated assays or ELISA. We calculated their ability to predict the need for dialysis post-transplant and correlated with the estimated time to a 50% reduction in plasma creatinine (tCr50), measured glomerular filtration rate (mGFR) and estimated GFR (eGFR).ResultsAll biomarkers measured at Day 1, except urinary L-FABP, significantly correlated with tCr50 and mGFR at Day 5. Plasma NGAL at Day 1 and a timed urine output predicted DGF (AUC = 0.91 and AUC 0.98). Nil or only weak correlations were identified between early bio-arker levels and mGFR or eGFR at three or twelve months.ConclusionHigh plasma NGAL at Day 1 predicts DGF and is associated with initial graft function, but may not prove better than P-creatinine or a timed urine output. Early biomarker levels do not correlate with one-year graft function.Trial registrationClinicalTrials.gov NCT01395719

KW - GELATINASE-ASSOCIATED LIPOCALIN

KW - ACID-BINDING PROTEIN

KW - GLOMERULAR-FILTRATION-RATE

KW - RENAL-TRANSPLANTATION

KW - CARDIAC DEATH

KW - CREATININE

KW - BIOMARKERS

KW - INJURY

KW - RECIPIENTS

KW - OUTCOMES

U2 - 10.1371/journal.pone.0212676

DO - 10.1371/journal.pone.0212676

M3 - Article

SN - 1932-6203

VL - 14

JO - PLOS-One

JF - PLOS-One

IS - 2

M1 - 0212676

ER -