Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy

Hendricus BA de Bont; Ruben GG Leenders; Johan W Scheeren; Hidde J Haisma; Dick de Vos

Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy

Hendricus BA de Bont (Inventor)
, Ruben GG Leenders (Inventor)
, Johan W Scheeren (Inventor)
, Hidde J Haisma (Inventor)
, Dick de Vos (Inventor)

Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

Research output: Patent

Abstract

A paclitaxel prodrug has a paclitaxel portion coupled to a cleavable N-(aliphatic or aromatic)-O-glycosyl carbamate spacer group, and can be administered orally, topically or by injection to provide an anti-tumor effect, the prodrug being activated by a hydrolizing enzyme, an endogeneous enzyme or an exogeneous enzyme.

Original language	English
Patent number	US5760072
IPC	C07H 13/ 12 A I
Priority date	29/12/1995
Publication status	Published - 2-Jun-1998

Handle.net

Persistent link

Cite this

@misc{103cdaa4b7fe408db0a954293863ff0b,

title = "Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy",

abstract = "A paclitaxel prodrug has a paclitaxel portion coupled to a cleavable N-(aliphatic or aromatic)-O-glycosyl carbamate spacer group, and can be administered orally, topically or by injection to provide an anti-tumor effect, the prodrug being activated by a hydrolizing enzyme, an endogeneous enzyme or an exogeneous enzyme.",

author = "\{de Bont\}, \{Hendricus BA\} and Leenders, \{Ruben GG\} and Scheeren, \{Johan W\} and Haisma, \{Hidde J\} and \{de Vos\}, Dick",

note = "US Patent 5,760,072; US5760072; C07H 13/ 12 A I",

year = "1998",

month = jun,

day = "2",

language = "English",

type = "Patent",

}

TY - PAT

T1 - Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy

AU - de Bont, Hendricus BA

AU - Leenders, Ruben GG

AU - Scheeren, Johan W

AU - Haisma, Hidde J

AU - de Vos, Dick

N1 - US Patent 5,760,072

PY - 1998/6/2

Y1 - 1998/6/2

N2 - A paclitaxel prodrug has a paclitaxel portion coupled to a cleavable N-(aliphatic or aromatic)-O-glycosyl carbamate spacer group, and can be administered orally, topically or by injection to provide an anti-tumor effect, the prodrug being activated by a hydrolizing enzyme, an endogeneous enzyme or an exogeneous enzyme.

AB - A paclitaxel prodrug has a paclitaxel portion coupled to a cleavable N-(aliphatic or aromatic)-O-glycosyl carbamate spacer group, and can be administered orally, topically or by injection to provide an anti-tumor effect, the prodrug being activated by a hydrolizing enzyme, an endogeneous enzyme or an exogeneous enzyme.

M3 - Patent

M1 - US5760072

ER -

Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy

Abstract

Handle.net

Fingerprint

Cite this