Pain, not chronic disease, is associated with the recurrence of depressive and anxiety disorders

Marloes M. J. G. y Gerrits*, Patricia van Oppen, Stephanie S. Leone, Harm W. J. van Marwijk, Henriette E. van der Horst, Brenda W. Penninx

*Corresponding author for this work

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    Abstract

    Background: Studies suggest that poor physical health might be associated with increased depression and anxiety recurrence. The objectives of this study were to determine whether specific chronic diseases and pain characteristics are associated with depression and anxiety recurrence and to examine whether such associations are mediated by subthreshold depressive or anxiety symptoms.

    Methods: 1122 individuals with remitted depressive or anxiety disorder (Netherlands Study of Depression and Anxiety) were followed up for a period of four years. The impact of specific chronic diseases and pain characteristics on recurrence was assessed using Cox regression and mediation analyses.

    Results: Chronic diseases were not associated with recurrence. Neck (HR 1.45, p <.01), chest (HR 1.65, p <.01), abdominal (HR 1.52, p <.01) pain, an increase in the number of pain locations (HR 1.10, p <.01) and pain severity (HR 1.18, p = .01) were associated with an increased risk of depression recurrence but not anxiety. Subthreshold depressive symptoms mediated the associations between pain and depression recurrence.

    Conclusions: Pain, not chronic disease, increases the likelihood of depression recurrence, largely through its association with aggravated subthreshold depressive symptoms. These findings support the idea of the existence of a mutually reinforcing mechanism between pain and depression and are indicative of the importance of shedding light on neurobiological links in order to optimize pain and depression management.

    Original languageEnglish
    Article number187
    Number of pages9
    JournalBMC Psychiatry
    Volume14
    DOIs
    Publication statusPublished - 25-Jun-2014

    Keywords

    • Depressive disorder
    • Anxiety disorder
    • Recurrence
    • Pain
    • Chronic diseases
    • COMORBID MEDICAL ILLNESS
    • CHRONIC SOMATIC DISEASES
    • MENTAL-HEALTH SURVEY
    • PRIMARY-CARE
    • MAJOR DEPRESSION
    • PSYCHOMETRIC PROPERTIES
    • GENERAL-POPULATION
    • COLLABORATIVE-CARE
    • PANIC DISORDER
    • FOLLOW-UP

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