Abstract
A highly regioselective direct cross‐coupling of internal alkenes of α‐oxoketene dithioacetals with terminal alkenes has been successfully realized by palladium‐catalyzed CH bond activation, affording functionalized 1,3‐butadienes. Condensation of the resultant 1,3‐butadienes by diamines efficiently produced potentially bioactive bicyclic pyridone derivatives (see scheme).
Original language | English |
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Pages (from-to) | 5792-5797 |
Number of pages | 6 |
Journal | Angewandte Chemie - International Edition |
Volume | 49 |
Issue number | 33 |
DOIs | |
Publication status | Published - 2010 |
Externally published | Yes |
Keywords
- alkenes
- alkenylation
- C-H activation
- heterocycles
- palladium
- PD(II)-CATALYZED OLEFINATION
- DIRECT ALKENYLATION
- DIRECT ARYLATION
- DERIVATIVES
- CYCLIZATION
- REACTIVITY
- COMPLEXES
- ACRYLATES
- LIBRARY
- INDOLES