Pancreatitis associated with the use of itraconazole

J L M Passier; E P van Puijenbroek; G J P M Jonkers; A C van Grootheest

Pancreatitis associated with the use of itraconazole

J L M Passier, E P van Puijenbroek, G J P M Jonkers, A C van Grootheest

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: We call attention to the assumed association between itraconazole and pancreatitis by presentation of four Dutch case reports.

METHODS AND RESULTS: The Netherlands Pharmacovigilance Centre Lareb received four reports of pancreatitis associated with the use of itraconazole, all reported by health professionals. The diagnosis of pancreatitis was confirmed by diagnostic tests. All four patients had been using relatively high doses of itraconazole. In two of these cases, recurrent use of itraconazole resulted in recurrent symptoms. We describe these four cases and discuss the possible mechanism.

CONCLUSIONS: The presented cases suggest a causal relation between itraconazole and pancreatitis. Given the often mild indication for the use of itraconazole and the seriousness of this possible adverse drug reaction, it is essential that more data are obtained in order to strengthen the causality of this association. Physicians are invited to report their experiences on the subject.

Original language	English
Pages (from-to)	285-289
Number of pages	5
Journal	The Netherlands Journal of Medicine
Volume	68
Issue number	6
Publication status	Published - Jun-2010

Keywords

Acute Disease
Adolescent
Aged
Antifungal Agents
Female
Humans
Itraconazole
Male
Middle Aged
Pancreatitis

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@article{f62ea992aeb94a2498dde51c772c9659,

title = "Pancreatitis associated with the use of itraconazole",

abstract = "BACKGROUND: We call attention to the assumed association between itraconazole and pancreatitis by presentation of four Dutch case reports.METHODS AND RESULTS: The Netherlands Pharmacovigilance Centre Lareb received four reports of pancreatitis associated with the use of itraconazole, all reported by health professionals. The diagnosis of pancreatitis was confirmed by diagnostic tests. All four patients had been using relatively high doses of itraconazole. In two of these cases, recurrent use of itraconazole resulted in recurrent symptoms. We describe these four cases and discuss the possible mechanism.CONCLUSIONS: The presented cases suggest a causal relation between itraconazole and pancreatitis. Given the often mild indication for the use of itraconazole and the seriousness of this possible adverse drug reaction, it is essential that more data are obtained in order to strengthen the causality of this association. Physicians are invited to report their experiences on the subject.",

keywords = "Acute Disease, Adolescent, Aged, Antifungal Agents, Female, Humans, Itraconazole, Male, Middle Aged, Pancreatitis",

author = "Passier, {J L M} and {van Puijenbroek}, {E P} and Jonkers, {G J P M} and {van Grootheest}, {A C}",

year = "2010",

month = jun,

language = "English",

volume = "68",

pages = "285--289",

journal = "The Netherlands Journal of Medicine",

issn = "0300-2977",

publisher = "van Zuiden Communications BV.",

number = "6",

}

TY - JOUR

T1 - Pancreatitis associated with the use of itraconazole

AU - Passier, J L M

AU - van Puijenbroek, E P

AU - Jonkers, G J P M

AU - van Grootheest, A C

PY - 2010/6

Y1 - 2010/6

N2 - BACKGROUND: We call attention to the assumed association between itraconazole and pancreatitis by presentation of four Dutch case reports.METHODS AND RESULTS: The Netherlands Pharmacovigilance Centre Lareb received four reports of pancreatitis associated with the use of itraconazole, all reported by health professionals. The diagnosis of pancreatitis was confirmed by diagnostic tests. All four patients had been using relatively high doses of itraconazole. In two of these cases, recurrent use of itraconazole resulted in recurrent symptoms. We describe these four cases and discuss the possible mechanism.CONCLUSIONS: The presented cases suggest a causal relation between itraconazole and pancreatitis. Given the often mild indication for the use of itraconazole and the seriousness of this possible adverse drug reaction, it is essential that more data are obtained in order to strengthen the causality of this association. Physicians are invited to report their experiences on the subject.

AB - BACKGROUND: We call attention to the assumed association between itraconazole and pancreatitis by presentation of four Dutch case reports.METHODS AND RESULTS: The Netherlands Pharmacovigilance Centre Lareb received four reports of pancreatitis associated with the use of itraconazole, all reported by health professionals. The diagnosis of pancreatitis was confirmed by diagnostic tests. All four patients had been using relatively high doses of itraconazole. In two of these cases, recurrent use of itraconazole resulted in recurrent symptoms. We describe these four cases and discuss the possible mechanism.CONCLUSIONS: The presented cases suggest a causal relation between itraconazole and pancreatitis. Given the often mild indication for the use of itraconazole and the seriousness of this possible adverse drug reaction, it is essential that more data are obtained in order to strengthen the causality of this association. Physicians are invited to report their experiences on the subject.

KW - Acute Disease

KW - Adolescent

KW - Aged

KW - Antifungal Agents

KW - Female

KW - Humans

KW - Itraconazole

KW - Male

KW - Middle Aged

KW - Pancreatitis

M3 - Article

C2 - 20558863

SN - 0300-2977

VL - 68

SP - 285

EP - 289

JO - The Netherlands Journal of Medicine

JF - The Netherlands Journal of Medicine

IS - 6

ER -

Pancreatitis associated with the use of itraconazole

Abstract

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