Paradoxical down-regulation of p16(INK4a) mRNA with advancing age in Acute Myeloid Leukemia

Hendrik J. M. de Jonge; Carolien M. Woolthuis; Eveline S. J. M. de Bont; Gerwin Huls

doi:10.18632/aging.100096

Paradoxical down-regulation of p16(INK4a) mRNA with advancing age in Acute Myeloid Leukemia

Hendrik J. M. de Jonge, Carolien M. Woolthuis, Eveline S. J. M. de Bont, Gerwin Huls^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Aging is generally considered to be the consequence of stem cell attrition caused by the activity of tumor suppressor pathways that censor potentially malignant clones by eliciting apoptosis or senescence. An important effector of aging is the cyclin-dependent kinase inhibitor p16(INK4a), which is also a known suppressor of cancer. The expression of p16(INK4a) is very low or absent in young organisms but increases with advancing age. We recently showed that, unlike healthy cells, acute myeloid leukemia (AML) derived blasts show a down-regulation of p16(INK4a) mRNA with increasing age. Based on this observation we hypothesize that suppression of defense mechanisms which protect older cells against cellular and DNA damage might facilitate oncogenesis in older individuals.

Original language	English
Pages (from-to)	949-953
Number of pages	5
Journal	Aging-Us
Volume	1
Issue number	11
DOIs	https://doi.org/10.18632/aging.100096
Publication status	Published - Nov-2009

Keywords

p16(INK4a)
aging
Acute Myeloid Leukemia
senescence
HEMATOPOIETIC STEM-CELLS
SELF-RENEWAL
TUMOR-SUPPRESSOR
HEART-FAILURE
EXPRESSION
SENESCENCE
CANCER
GROWTH
BMI-1
OLDER

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@article{59067f09fb6f42019998b7e34289e7e4,

title = "Paradoxical down-regulation of p16(INK4a) mRNA with advancing age in Acute Myeloid Leukemia",

abstract = "Aging is generally considered to be the consequence of stem cell attrition caused by the activity of tumor suppressor pathways that censor potentially malignant clones by eliciting apoptosis or senescence. An important effector of aging is the cyclin-dependent kinase inhibitor p16(INK4a), which is also a known suppressor of cancer. The expression of p16(INK4a) is very low or absent in young organisms but increases with advancing age. We recently showed that, unlike healthy cells, acute myeloid leukemia (AML) derived blasts show a down-regulation of p16(INK4a) mRNA with increasing age. Based on this observation we hypothesize that suppression of defense mechanisms which protect older cells against cellular and DNA damage might facilitate oncogenesis in older individuals.",

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author = "{de Jonge}, {Hendrik J. M.} and Woolthuis, {Carolien M.} and {de Bont}, {Eveline S. J. M.} and Gerwin Huls",

year = "2009",

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T1 - Paradoxical down-regulation of p16(INK4a) mRNA with advancing age in Acute Myeloid Leukemia

AU - de Jonge, Hendrik J. M.

AU - Woolthuis, Carolien M.

AU - de Bont, Eveline S. J. M.

AU - Huls, Gerwin

PY - 2009/11

Y1 - 2009/11

N2 - Aging is generally considered to be the consequence of stem cell attrition caused by the activity of tumor suppressor pathways that censor potentially malignant clones by eliciting apoptosis or senescence. An important effector of aging is the cyclin-dependent kinase inhibitor p16(INK4a), which is also a known suppressor of cancer. The expression of p16(INK4a) is very low or absent in young organisms but increases with advancing age. We recently showed that, unlike healthy cells, acute myeloid leukemia (AML) derived blasts show a down-regulation of p16(INK4a) mRNA with increasing age. Based on this observation we hypothesize that suppression of defense mechanisms which protect older cells against cellular and DNA damage might facilitate oncogenesis in older individuals.

AB - Aging is generally considered to be the consequence of stem cell attrition caused by the activity of tumor suppressor pathways that censor potentially malignant clones by eliciting apoptosis or senescence. An important effector of aging is the cyclin-dependent kinase inhibitor p16(INK4a), which is also a known suppressor of cancer. The expression of p16(INK4a) is very low or absent in young organisms but increases with advancing age. We recently showed that, unlike healthy cells, acute myeloid leukemia (AML) derived blasts show a down-regulation of p16(INK4a) mRNA with increasing age. Based on this observation we hypothesize that suppression of defense mechanisms which protect older cells against cellular and DNA damage might facilitate oncogenesis in older individuals.

KW - p16(INK4a)

KW - aging

KW - Acute Myeloid Leukemia

KW - senescence

KW - HEMATOPOIETIC STEM-CELLS

KW - SELF-RENEWAL

KW - TUMOR-SUPPRESSOR

KW - HEART-FAILURE

KW - EXPRESSION

KW - SENESCENCE

KW - CANCER

KW - GROWTH

KW - BMI-1

KW - OLDER

U2 - 10.18632/aging.100096

DO - 10.18632/aging.100096

M3 - Article

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SN - 1945-4589

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JO - Aging-Us

JF - Aging-Us

IS - 11

ER -

Paradoxical down-regulation of p16(INK4a) mRNA with advancing age in Acute Myeloid Leukemia

Abstract

Keywords

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