Parallel synthesis of arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles by IMCR: a novel class of aspartyl protease inhibitors

Alexander Doemling*, Barbara Beck, Eberhardt Herdtweck, Walfrido Antuch, Christian Oefner, Nasser Yehia, Adoracion Gracia-Marques

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

The synthesis of a novel class of potential aspartyl-protease inhibitors is described. Arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles have been assembled by parallel synthesis using an isocyanide-based multi component reaction (vL-3CR).

Original languageEnglish
Pages (from-to)99-109
Number of pages11
JournalArkivoc
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • aspartyl protease inhibitor
  • van Leusen
  • isocyanide
  • IMCR
  • SUBSTITUTED PIPERIDINES
  • IMIDAZOLES
  • PROTEINASES
  • CHEMISTRY

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