Parallel synthesis of arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles by IMCR: a novel class of aspartyl protease inhibitors

Alexander Doemling; Barbara Beck; Eberhardt Herdtweck; Walfrido Antuch; Christian Oefner; Nasser Yehia; Adoracion Gracia-Marques

Parallel synthesis of arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles by IMCR: a novel class of aspartyl protease inhibitors

Alexander Doemling^*, Barbara Beck, Eberhardt Herdtweck, Walfrido Antuch, Christian Oefner, Nasser Yehia, Adoracion Gracia-Marques

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

Abstract

The synthesis of a novel class of potential aspartyl-protease inhibitors is described. Arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles have been assembled by parallel synthesis using an isocyanide-based multi component reaction (vL-3CR).

Original language	English
Pages (from-to)	99-109
Number of pages	11
Journal	Arkivoc
Publication status	Published - 2007
Externally published	Yes

Keywords

aspartyl protease inhibitor
van Leusen
isocyanide
IMCR
SUBSTITUTED PIPERIDINES
IMIDAZOLES
PROTEINASES
CHEMISTRY

Cite this

@article{10956159dd9b4fee9c88c67a204d3cc0,

title = "Parallel synthesis of arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles by IMCR: a novel class of aspartyl protease inhibitors",

abstract = "The synthesis of a novel class of potential aspartyl-protease inhibitors is described. Arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles have been assembled by parallel synthesis using an isocyanide-based multi component reaction (vL-3CR).",

keywords = "aspartyl protease inhibitor, van Leusen, isocyanide, IMCR, SUBSTITUTED PIPERIDINES, IMIDAZOLES, PROTEINASES, CHEMISTRY",

author = "Alexander Doemling and Barbara Beck and Eberhardt Herdtweck and Walfrido Antuch and Christian Oefner and Nasser Yehia and Adoracion Gracia-Marques",

year = "2007",

language = "English",

pages = "99--109",

journal = "Arkivoc",

issn = "1424-6376",

}

Parallel synthesis of arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles by IMCR : a novel class of aspartyl protease inhibitors. / Doemling, Alexander; Beck, Barbara; Herdtweck, Eberhardt; Antuch, Walfrido; Oefner, Christian; Yehia, Nasser; Gracia-Marques, Adoracion.

In: Arkivoc, 2007, p. 99-109.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Parallel synthesis of arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles by IMCR

T2 - a novel class of aspartyl protease inhibitors

AU - Doemling, Alexander

AU - Beck, Barbara

AU - Herdtweck, Eberhardt

AU - Antuch, Walfrido

AU - Oefner, Christian

AU - Yehia, Nasser

AU - Gracia-Marques, Adoracion

PY - 2007

Y1 - 2007

N2 - The synthesis of a novel class of potential aspartyl-protease inhibitors is described. Arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles have been assembled by parallel synthesis using an isocyanide-based multi component reaction (vL-3CR).

AB - The synthesis of a novel class of potential aspartyl-protease inhibitors is described. Arrays of 1,4,5-trisubstituted 1-(4-piperidyl)-imidazoles have been assembled by parallel synthesis using an isocyanide-based multi component reaction (vL-3CR).

KW - aspartyl protease inhibitor

KW - van Leusen

KW - isocyanide

KW - IMCR

KW - SUBSTITUTED PIPERIDINES

KW - IMIDAZOLES

KW - PROTEINASES

KW - CHEMISTRY

M3 - Article

SP - 99

EP - 109

JO - Arkivoc

JF - Arkivoc

SN - 1424-6376

ER -