Partial recovery of exocrine pancreatic function and intestinal fat absorption after ivacaftor treatment

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Objectives: Ivacaftor treatment results in rapid improvement of lung function and weight gain. We hypothesize that the reported ivacaftor induced weight gain is related to recovery of exocrine pancreatic function and improved intestinal fat absorption. Methods: We measured fecal elastase-1 (FE), FEV1 and body height and weight, in a 13-year old girl with CF (dF508/S1251N) with proven pancreatic insufficiency (FE
Original languageEnglish
Number of pages1
Publication statusPublished - 1-Jun-2015


  • ivacaftor
  • iron
  • triacylglycerol lipase
  • elastase
  • pancreas function
  • lipid absorption
  • European
  • cystic fibrosis
  • body weight gain
  • human
  • patient
  • caloric intake
  • body weight
  • general condition
  • body height
  • fat intake
  • pancreatic insufficiency
  • energy expenditure
  • girl
  • female
  • dietary intake
  • weight
  • case study
  • energy absorption
  • lung function

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