Paternal Age and Risk of Autism in an Ethnically Diverse, Non-Industrialized Setting: Aruba

Ingrid D. C. van Balkom; Michaeline Bresnahan; Pieter Jelle Vuijk; Jan Hubert; Ezra Susser; Hans W. Hoek

doi:10.1371/journal.pone.0045090

Paternal Age and Risk of Autism in an Ethnically Diverse, Non-Industrialized Setting: Aruba

Ingrid D. C. van Balkom
, Michaeline Bresnahan
, Pieter Jelle Vuijk
, Jan Hubert
, Ezra Susser
, Hans W. Hoek

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

262 Downloads (Pure)

Abstract

Objective: The aim of this study was to examine paternal age in relation to risk of autism spectrum disorders (ASDs) in a setting other than the industrialized west.

Design: A case-control study of Aruban-born children (1990-2003). Cases (N = 95) were identified at the Child and Adolescent Psychiatry Clinic, the only such clinic in Aruba; gender and age matched controls (N = 347) were gathered from public health records. Parental age was defined categorically (= 50y). The analysis was made, using conditional logistic regression.

Results: Advanced paternal age was associated with increased risk of ASDs in offspring. In comparison to the youngest paternal age group (

Conclusion: This study, part of the first epidemiologic study of autism in the Caribbean, contributes additional evidence, from a distinctive sociocultural setting, of the risk of ASD associated with increased paternal age.

Original language	English
Article number	e45090
Number of pages	4
Journal	PLoS ONE
Volume	7
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0045090
Publication status	Published - 11-Sept-2012

Keywords

SPECTRUM DISORDERS
PERINATAL FACTORS
BIRTH-WEIGHT
POPULATION
PRETERM
TRAITS

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title = "Paternal Age and Risk of Autism in an Ethnically Diverse, Non-Industrialized Setting: Aruba",

abstract = "Objective: The aim of this study was to examine paternal age in relation to risk of autism spectrum disorders (ASDs) in a setting other than the industrialized west.Design: A case-control study of Aruban-born children (1990-2003). Cases (N = 95) were identified at the Child and Adolescent Psychiatry Clinic, the only such clinic in Aruba; gender and age matched controls (N = 347) were gathered from public health records. Parental age was defined categorically (= 50y). The analysis was made, using conditional logistic regression.Results: Advanced paternal age was associated with increased risk of ASDs in offspring. In comparison to the youngest paternal age group (Conclusion: This study, part of the first epidemiologic study of autism in the Caribbean, contributes additional evidence, from a distinctive sociocultural setting, of the risk of ASD associated with increased paternal age.",

keywords = "SPECTRUM DISORDERS, PERINATAL FACTORS, BIRTH-WEIGHT, POPULATION, PRETERM, TRAITS",

author = "\{van Balkom\}, \{Ingrid D. C.\} and Michaeline Bresnahan and Vuijk, \{Pieter Jelle\} and Jan Hubert and Ezra Susser and Hoek, \{Hans W.\}",

year = "2012",

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doi = "10.1371/journal.pone.0045090",

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AU - van Balkom, Ingrid D. C.

AU - Bresnahan, Michaeline

AU - Vuijk, Pieter Jelle

AU - Hubert, Jan

AU - Susser, Ezra

AU - Hoek, Hans W.

PY - 2012/9/11

Y1 - 2012/9/11

N2 - Objective: The aim of this study was to examine paternal age in relation to risk of autism spectrum disorders (ASDs) in a setting other than the industrialized west.Design: A case-control study of Aruban-born children (1990-2003). Cases (N = 95) were identified at the Child and Adolescent Psychiatry Clinic, the only such clinic in Aruba; gender and age matched controls (N = 347) were gathered from public health records. Parental age was defined categorically (= 50y). The analysis was made, using conditional logistic regression.Results: Advanced paternal age was associated with increased risk of ASDs in offspring. In comparison to the youngest paternal age group (Conclusion: This study, part of the first epidemiologic study of autism in the Caribbean, contributes additional evidence, from a distinctive sociocultural setting, of the risk of ASD associated with increased paternal age.

AB - Objective: The aim of this study was to examine paternal age in relation to risk of autism spectrum disorders (ASDs) in a setting other than the industrialized west.Design: A case-control study of Aruban-born children (1990-2003). Cases (N = 95) were identified at the Child and Adolescent Psychiatry Clinic, the only such clinic in Aruba; gender and age matched controls (N = 347) were gathered from public health records. Parental age was defined categorically (= 50y). The analysis was made, using conditional logistic regression.Results: Advanced paternal age was associated with increased risk of ASDs in offspring. In comparison to the youngest paternal age group (Conclusion: This study, part of the first epidemiologic study of autism in the Caribbean, contributes additional evidence, from a distinctive sociocultural setting, of the risk of ASD associated with increased paternal age.

KW - SPECTRUM DISORDERS

KW - PERINATAL FACTORS

KW - BIRTH-WEIGHT

KW - POPULATION

KW - PRETERM

KW - TRAITS

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Paternal Age and Risk of Autism in an Ethnically Diverse, Non-Industrialized Setting: Aruba

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Keywords

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