Pathobiology of acute respiratory distress syndrome

Pediatric Acute Lung Injury Consensus Conference Group, Anil Sapru, Heidi Flori, Michael W Quasney, Mary K Dahmer

Research output: Contribution to journalArticleAcademicpeer-review

54 Citations (Scopus)

Abstract

The unique characteristics of pulmonary circulation and alveolar-epithelial capillary-endothelial barrier allow for maintenance of the air-filled, fluid-free status of the alveoli essential for facilitating gas exchange, maintaining alveolar stability, and defending the lung against inhaled pathogens. The hallmark of pathophysiology in acute respiratory distress syndrome is the loss of the alveolar capillary permeability barrier and the presence of protein-rich edema fluid in the alveoli. This alteration in permeability and accumulation of fluid in the alveoli accompanies damage to the lung epithelium and vascular endothelium along with dysregulated inflammation and inappropriate activity of leukocytes and platelets. In addition, there is uncontrolled activation of coagulation along with suppression of fibrinolysis and loss of surfactant. These pathophysiological changes result in the clinical manifestations of acute respiratory distress syndrome, which include hypoxemia, radiographic opacities, decreased functional residual capacity, increased physiologic deadspace, and decreased lung compliance. Resolution of acute respiratory distress syndrome involves the migration of cells to the site of injury and re-establishment of the epithelium and endothelium with or without the development of fibrosis. Most of the data related to acute respiratory distress syndrome, however, originate from studies in adults or in mature animals with very few studies performed in children or juvenile animals. The lack of studies in children is particularly problematic because the lungs and immune system are still developing during childhood and consequently the pathophysiology of pediatric acute respiratory distress syndrome may differ in significant ways from that seen in acute respiratory distress syndrome in adults. This article describes what is known of the pathophysiologic processes of pediatric acute respiratory distress syndrome as we know it today while also presenting the much greater body of evidence on these processes as elucidated by adult and animal studies. It is also our expressed intent to generate enthusiasm for larger and more in-depth investigations of the mechanisms of disease and repair specific to children in the years to come.

Original languageEnglish
Pages (from-to)S6-S22
Number of pages17
JournalPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Volume16
Issue number5 Suppl 1
DOIs
Publication statusPublished - Jun-2015

Keywords

  • Acute Disease
  • Endothelium, Vascular/metabolism
  • Humans
  • Inflammation/metabolism
  • Pulmonary Alveoli/metabolism
  • Pulmonary Circulation/physiology
  • Pulmonary Edema/physiopathology
  • Pulmonary Surfactants/metabolism
  • Respiratory Distress Syndrome, Newborn/physiopathology
  • Respiratory Mucosa/metabolism
  • Thrombosis/physiopathology

Cite this