Pathogenesis of Sjögren's

Alexandre Dumusc, Francesca Barone, Saba Nayar, Arjan Vissink, Benjamin A. Fisher, Simon J. Bowman

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


The pathogenesis of primary Sjögren's (pSS) remains an area of intense research. A triggering factor, either endogenous, leading to autoantigen release, or an external factor such as a virus, is thought to trigger inflammation of the ductal epithelial cells (autoimmune epitheliitis) and chronic focal inflammation of exocrine glands by inflammatory cells with a consequential reduction in glandular function. There is also a strong genetic link between HLA-DR3 and high levels of anti-Ro/La antibodies. More recently, gene association studies have confirmed this along with associations with genes involved in B-cell activation, type-I interferons, IL-12 and the innate immune system. Other immunological studies have also identified mechanisms of B and T-cell activation, activation of the type-I interferon pathway and a potential role for epigenetics in the pathogenesis of primary SS.
Original languageEnglish
Title of host publicationDubois' Lupus Erythematosus and Related Syndromes
EditorsDaniel J. Wallace, Bevra Hannahs Hahn
Number of pages2
ISBN (Electronic)9780323550642, 9780323550659
ISBN (Print)9780323479271
Publication statusPublished - 18-Oct-2018

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