Pathogenesis of Sjögren's

Alexandre Dumusc, Francesca Barone, Saba Nayar, Arjan Vissink, Benjamin A. Fisher, Simon J. Bowman

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

The pathogenesis of primary Sjögren's (pSS) remains an area of intense research. A triggering factor, either endogenous, leading to autoantigen release, or an external factor such as a virus, is thought to trigger inflammation of the ductal epithelial cells (autoimmune epitheliitis) and chronic focal inflammation of exocrine glands by inflammatory cells with a consequential reduction in glandular function. There is also a strong genetic link between HLA-DR3 and high levels of anti-Ro/La antibodies. More recently, gene association studies have confirmed this along with associations with genes involved in B-cell activation, type-I interferons, IL-12 and the innate immune system. Other immunological studies have also identified mechanisms of B and T-cell activation, activation of the type-I interferon pathway and a potential role for epigenetics in the pathogenesis of primary SS.
Original languageEnglish
Title of host publicationDubois' Lupus Erythematosus and Related Syndromes
EditorsDaniel J. Wallace, Bevra Hannahs Hahn
PublisherElsevier
Chapter25
Pages338-339
Number of pages2
Edition9th
ISBN (Electronic)9780323550642, 9780323550659
ISBN (Print)9780323479271
Publication statusPublished - 18-Oct-2018

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