Pathways of Unconventional Protein Secretion

Catherine Rabouille*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    180 Citations (Scopus)

    Abstract

    Secretory proteins are conventionally transported through the endoplasmic reticulum to the Golgi and then to the plasma membrane where they are released into the extracellular space. However, numerous substrates also reach these destinations using unconventional pathways. Unconventional protein secretion (UPS) is complex and comprises cargos without a signal peptide or a transmembrane domain that can translocate across the plasma membrane, and cargos that reach the plasma membrane by bypassing the Golgi despite entering the endoplasmic reticulum (ER). With a few exceptions, unconventional secretion is largely triggered by stress. Here I review new results and concepts that are beginning to define these pathways.

    Original languageEnglish
    Pages (from-to)230-240
    Number of pages11
    JournalTrends in Cell Biology
    Volume27
    Issue number3
    DOIs
    Publication statusPublished - Mar-2017

    Keywords

    • GROWTH-FACTOR 2
    • HEPARAN-SULFATE PROTEOGLYCANS
    • HIV-1 TAT
    • MAMMALIAN-CELLS
    • AUTOPHAGY
    • GRASP
    • TRAFFICKING
    • MECHANISMS
    • DROSOPHILA
    • FIBROBLAST-GROWTH-FACTOR-2

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